Mucopenetrating micelles with a PEG corona
| Autor: | Yan Zhang, Essi Taipaleenmäki, Sidsel A. Mouritzen, Brigitte Städler, Philipp Schattling |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Nile red Nanoparticle 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Methacrylate 01 natural sciences Micelle 0104 chemical sciences chemistry.chemical_compound chemistry Chemical engineering Polymer chemistry PEG ratio Copolymer General Materials Science 0210 nano-technology Caprolactone Ethylene glycol |
| Zdroj: | Taipaleenmäki, E M, Mouritzen, S, Schattling, P, Zhang, Y & Stadler, B M 2017, ' Mucopenetrating Micelles with a PEG Corona ', Nanoscale, vol. 9, no. 46, pp. 18438-18448 . https://doi.org/10.1039/C7NR06821B |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c7nr06821b |
| Popis: | Crossing the intestinal mucus layer is a long-standing challenge for orally delivered nanoparticles carrying therapeutic cargo. We report the assembly of mucopenetrating cargo-loaded micelles using block copolymers consisting of either linear poly(ethylene glycol) (PEG) or bottle-brush poly(oligo(ethylene glycol)methacrylate) (PEGb) as the hydrophilic block and poly(caprolactone) (PCL) or poly(cholesteryl methacrylate) (PCMA) as the hydrophobic extension. The micelles were shown to preserve their stability and retain ∼50% of their cargo in simulated gastric fluid. The ability of micelles to diffuse through reconstituted porcine mucus was assessed in a microfluidic set-up. Finally, the delivery of Nile Red as a hydrophobic model cargo across a mucus layer produced by epithelial cells was demonstrated. These engineered mucopenetrating micelles have potential to be developed into efficient absorption enhancers, contributing a nanotechnology solution to oral drug delivery. |
| Databáze: | OpenAIRE |
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