Clinical experience with insulin detemir type 2 diabetes mellitus, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Rabat-Sale-Zemmour-Zaer Region cohort of the A 1 chieve study
| Autor: | Ghizlane Belmejdoub, Abdelmjid Chraibi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases type 2 diabetes mellitus A1chieve study Endocrinology Diabetes and Metabolism insulin analogues Type 2 diabetes lcsh:Diseases of the endocrine glands. Clinical endocrinology Insulin aspart Endocrinology A 1 chieve study Internal medicine medicine lcsh:RC799-869 Insulin detemir lcsh:RC648-665 business.industry Type 2 Diabetes Mellitus nutritional and metabolic diseases Rabat-Sale-Zemmour-Zaer medicine.disease Biphasic insulin aspart Cohort Original Article lcsh:Diseases of the digestive system. Gastroenterology business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Indian Journal of Endocrinology and Metabolism, Vol 17, Iss 8, Pp 413-417 (2013) Indian Journal of Endocrinology and Metabolism |
| ISSN: | 2230-9500 2230-8210 |
| Popis: | Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66 726) in routine clinical care across four continents. Materials and Methods: Data was collected at baseline, at 12 weeks and at 24 weeks. This short communication presents the results for patients enrolled from Rabat-Sale-Zemmour-Zaer region, Morocco. Results: A total of 424 patients were enrolled in the study. Four different insulin analogue regimens were used in the study. Study patients had started on or were switched to biphasic insulin aspart (n = 177), insulin detemir (n = 150), insulin aspart (n = 11), basal insulin plus insulin aspart (n = 45) and other insulin combinations (n = 41). At baseline glycaemic control was poor for both insulin naïve (mean HbA 1 c: 10.1%) and insulin user (mean HbA 1 c: 9.4%) groups. After 24 weeks of treatment, all the study groups showed improvement in HbA 1 c (insulin naïve: −2.5%, insulin users: −1.8%). Major hypoglycaemia was observed in the insulin user group after 24 weeks (0.1 events/patient-year). SADRs were reported in 0.5% of insulin users. Conclusion: Starting or switching to insulin analogues was associated with improvement in glycaemic control with a low rate of hypoglycaemia. |
| Databáze: | OpenAIRE |
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