Tuberculosis genetic epidemiology: A Latin American perspective
| Autor: | Louis Grandjean, Marc Woodman, Ilsa L. Haeusler |
|---|---|
| Přispěvatelé: | British Infection Society, Wellcome Trust, The Bill and Melinda Gates Foundation, Academy of Medical Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Latin Americans genetic association genotype epidemiological data Review phylogeny bacterial genome genetic variability Pathology genetics Genetics (clinical) disease course pathogenesis transmission multidrug-resistant tuberculosis 3. Good health Mycobacterium tuberculosis complex tuberculosis whole-genome sequencing horizontal gene transfer genetic epidemiology Tuberculosis lcsh:QH426-470 heredity phenotype 030106 microbiology gene sequence Biology bacterial transmission South and Central America Mycobacterium tuberculosis 03 medical and health sciences antibiotic resistome Multidrug-resistant tuberculosis Drug Resistance Bacterial geographic distribution Genetics medicine Humans Transmission human Genetic variability Whole-genome sequencing Genetic diversity nonhuman Molecular epidemiology molecular evolution South America biology.organism_classification medicine.disease lcsh:Genetics 030104 developmental biology Latin America Genetic epidemiology medical technology tuberculostatic agent pathology multidrug resistant tuberculosis purl.org/pe-repo/ocde/ford#1.06.07 [https] Demography |
| Zdroj: | Genes, Vol 10, Iss 1, p 53 (2019) Genes |
| Popis: | There are an estimated 10 million new cases of tuberculosis worldwide annually, with 282,000 new or relapsed cases each year reported from the Americas. With improvements in genome sequencing technology, it is now possible to study the genetic diversity of tuberculosis with much greater resolution. Although tuberculosis bacteria do not engage in horizontal gene transfer, the genome is far more variable than previously thought. The study of genome-wide variation in tuberculosis has improved our understanding of the evolutionary origins of tuberculosis, the arrival of tuberculosis in Latin America, the genetic determinants of drug resistance, and lineage-specific associations with important clinical phenotypes. This article reviews what is known about the arrival of tuberculosis in Latin America, the genetic diversity of tuberculosis in Latin America, and the genotypic determinants of clinical phenotypes. |
| Databáze: | OpenAIRE |
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