SOX11 as a minimal residual disease marker for Mantle cell lymphoma
| Autor: | Lene Hyldahl Ebbesen, Anita Tranberg Simonsen, Julie Støve Bødker, Charlotte Guldborg Nyvold, Hans Bentzen, Camilla Darum Sørensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Neoplasm Residual Chromosomal translocation Lymphoma Mantle-Cell Biology Translocation Genetic SOXC Transcription Factors medicine Biomarkers Tumor Neoplasm Humans Aged Monitoring Physiologic Neoplasm Staging Regulation of gene expression Aged 80 and over Chromosomes Human Pair 14 Messenger RNA Chromosomes Human Pair 11 Case-control study Hematology Middle Aged medicine.disease Minimal residual disease Lymphoma Gene Expression Regulation Neoplastic Oncology Tumor Markers Biological Case-Control Studies Mantle cell lymphoma Female |
| Zdroj: | Simonsen, A T, Sørensen, C D, Ebbesen, L H, Bødker, J S, Bentzen, H H N & Nyvold, C G 2014, ' SOX11 as a minimal residual disease marker for Mantle cell lymphoma ', Leukemia Research, vol. 38, no. 8, pp. 918-24 . https://doi.org/10.1016/j.leukres.2014.04.007 Simonsen, A T, Sørensen, C D, Ebbesen, L H, Bødker, J S, Bentzen, H H N & Nyvold, C G 2014, ' SOX11 as a minimal residual disease marker for Mantle cell lymphoma ', Leukemia Research, vol. 38, no. 8, pp. 918-924 . https://doi.org/10.1016/j.leukres.2014.04.007 |
| Popis: | Recent studies have identified SOX11 as a novel diagnostic marker for mantle cell lymphoma (MCL). We quantified SOX11 by a truly mRNA specific qPCR assay in longitudinal peripheral blood samples from 20 patients and evidenced a close relationship of SOX11 expression and clinical status of the patients. In eight patient courses we validated the expression of SOX11 using t(11;14) and demonstrated positive correlation of SOX11 and t(11;14) levels. To the best of our knowledge this is the first report stating that quantification of SOX11 can be used as an minimal residual disease marker equal to the key translocation t(11;14) in MCL. |
| Databáze: | OpenAIRE |
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