Prognostic value of suPAR and hsCRP on acute kidney injury after cardiac surgery
| Autor: | Rikke Vibeke Nielsen, Hanne Berg Ravn, Sebastian Roed Rasmussen, Sisse R. Ostrowski, Rasmus Mogelvang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Nephrology medicine.medical_specialty medicine.medical_treatment Cardiac anaesthesia 030232 urology & nephrology 030204 cardiovascular system & hematology urologic and male genital diseases lcsh:RC870-923 Receptors Urokinase Plasminogen Activator 03 medical and health sciences Postoperative Complications 0302 clinical medicine Internal medicine Odds Ratio Humans Medicine Renal replacement therapy Cardiac Surgical Procedures Aged Retrospective Studies Cardiopulmonary Bypass business.industry Acute kidney injury Retrospective cohort study Odds ratio Middle Aged Cardiac surgery Prognosis medicine.disease lcsh:Diseases of the genitourinary system. Urology Risk prediction C-Reactive Protein SuPAR Preoperative Period Female business Biomarkers Research Article Kidney disease |
| Zdroj: | BMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021) Rasmussen, S R, Nielsen, R V, Møgelvang, R, Ostrowski, S R & Ravn, H B 2021, ' Prognostic value of suPAR and hsCRP on acute kidney injury after cardiac surgery ', BMC Nephrology, vol. 22, 120 . https://doi.org/10.1186/s12882-021-02322-0 BMC Nephrology Rasmussen, S R, Nielsen, R V, Møgelvang, R, Ostrowski, S R & Ravn, H B 2021, ' Prognostic value of suPAR and hsCRP on acute kidney injury after cardiac surgery ', BMC Nephrology, vol. 22, no. 1, 120 . https://doi.org/10.1186/s12882-021-02322-0 |
| ISSN: | 1471-2369 |
| DOI: | 10.1186/s12882-021-02322-0 |
| Popis: | Background Acute kidney injury (AKI) represents a serious complication following cardiac surgery. Adverse outcome after cardiac surgery has been observed in the presence of elevated levels of soluble urokinase-type plasminogen activator receptor (suPAR) and high-sensitivity C-Reactive Protein (hsCRP). The aim of study was (i) to investigate the relationship between preoperative elevated levels of suPAR and hsCRP and postoperative AKI in unselected cardiac surgery patients and (ii) to assess whether the concentration of the biomarkers reflected severity of AKI. Methods In a retrospective observational study, biobank blood plasma samples (n = 924) from patients admitted for elective on-pump cardiac surgery were analysed for suPAR and hsCRP levels. The relation between suPAR and hsCRP-values and AKI (any stage), defined by the KDIGO (Kidney Disease: Improving Global Outcomes) criteria, was assessed using adjusted logistic regression. Further, the association between biomarkers and severity (KDIGO 1, KDIGO 2–3 and renal replacement therapy (RRT)) was assessed using adjusted logistic regression. Results Postoperative AKI (any stage) was observed in 327 patients (35.4 %). A doubling of preoperative suPAR corresponded to an adjusted odds ratio (OR) for postoperative AKI (any stage) of 1.62 (95 % CI 1.26–2.09, p p = 0.002), 2.44 (95 % CI 1.56–3.82, p p = 0.002), for KDIGO 1, KDIGO 2–3 and need for RRT, respectively. No significant association was found between elevated levels of hsCRP and any degree of AKI. Conclusions Increasing levels of suPAR, but not hsCRP, were associated with development and severity of AKI following on-pump cardiac surgery. |
| Databáze: | OpenAIRE |
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