Cardiac Resynchronization Therapy MOdular REgistry
| Autor: | Salvatore Ivan Caico, Giuseppe Stabile, Maurizio Malacrida, Antonio De Simone, Luigi Padeletti, Antonio D'Onofrio, Giuseppe Arena, Giosuè Mascioli, Gianluca Botto, Francesco Isola, Domenico Pecora, Patrizia Pepi, Pietro Palmisano, Emanuele Bertaglia, Giampiero Maglia |
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| Rok vydání: | 2013 |
| Předmět: |
Pacemaker
Artificial medicine.medical_specialty genetic structures medicine.medical_treatment Treatment outcome Cardiac resynchronization therapy Cardiac Resynchronization Therapy Electrocardiography Internal medicine Humans Medicine Prospective Studies Registries cardiovascular diseases Prospective cohort study Ultrasonography Heart Failure medicine.diagnostic_test business.industry General Medicine Prognosis Defibrillators Implantable Radiography Clinical trial Treatment Outcome Italy Multicenter study Research Design Sample Size cardiovascular system Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Medicine. 14:886-893 |
| ISSN: | 1558-2027 |
| DOI: | 10.2459/jcm.0b013e3283644bb2 |
| Popis: | A variable proportion, up to 30%, of patients who undergo cardiac resynchronization therapy (CRT) do not benefit from treatment. The aim of the Cardiac Resynchronization Therapy MOdular REgistry (CRT MORE) is to determine whether specific electrocardiographic and radiographic parameters can be used to predict clinical and echocardiographic response to CRT.The CRT MORE is a prospective, single-arm, multicenter cohort study designed to evaluate the electrocardiographic and radiographic predictors of response to CRT. All study patients receive a pacemaker or implantable defibrillator for CRT delivery in accordance with current guidelines. Enrollment started in December 2011 and is scheduled to end in November 2013. Approximately 1100 consecutive patients will be enrolled in 30 Italian centers and will be followed up for 60 months after implantation. The primary endpoint is the improvement in clinical (Clinical Composite Score) and echocardiographic (a decrease of ≥ 15% in left ventricular end-systolic volume) parameters at the 6-month follow-up visit.This study might provide important information about which electrocardiographic and radiographic parameters better predict CRT response. |
| Databáze: | OpenAIRE |
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