Curcumin Can Prevent the Changes in Cerebellar Structure and Function Induced by Sodium Metabisulfite in Rat
| Autor: | Ali Noorafshan, Mohammad-Amin Abdollahifar, Saied Karbalay-Doust, Reza Asadi-Golshan, Ali Rashidiani-Rashidabadi, Aghdas Poostpasand |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Cerebellum
Pathology medicine.medical_specialty cerebellum Sodium chemistry.chemical_element Pharmacology Neuroprotection histology Cellular and Molecular Neuroscience chemistry.chemical_compound sulfite Cortex (anatomy) Medicine curcumin rat business.industry Sodium metabisulfite medicine.anatomical_structure chemistry Distilled water Cerebellar cortex Curcumin Original Article Neurology (clinical) business |
| Zdroj: | Experimental Neurobiology |
| ISSN: | 2093-8144 1226-2560 |
| DOI: | 10.5607/en.2013.22.4.258 |
| Popis: | Sulfites are used as anti-microbial and anti-oxidant agents in the food and pharmaceutical industries. Curcumin, a flavonoid, is an Asian spice that shows neuroprotective activities. The current study aimed to stereologically assess the rats' cerebellar cortex and rotarod performance following sulfite exposure and determine the possible neuroprotective potential of curcumin. The rats were divided into five groups: distilled water, olive oil, curcumin (100 mg/kg/day), sodium metabisulfite (25 mg/kg/day), and sodium metabisulfite+curcumin. At 56 days after treatment, rotarod performance was tested, and then the cerebellum was removed for stereological analysis. The study results revealed 31%, 36%, 19% and 24% decrease in the total volume of the cerebellum, cortex, the total number of the Purkinje cells and length of the nerve fibers in the cortex per Purkinje, respectively in the sodium metabisulfite-treated rats compared to the distilled water group (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|