TRIGLYCERIDE METABOLISM IN THYROID DISEASE
| Autor: | B. R. Tulloch, Basil S. Lewis, T. Russell Fraser |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Thyroid Gland Triglyceride level Fatty Acids Nonesterified Thyroid Function Tests Hyperthyroidism Thyroid function tests chemistry.chemical_compound Internal medicine Myxedema medicine Humans Triglyceride metabolism Triglycerides medicine.diagnostic_test Triglyceride Cholesterol business.industry Thyroid disease Thyroid Fasting General Medicine Middle Aged medicine.disease Thyroid Diseases Thyroxine medicine.anatomical_structure Endocrinology Liver chemistry Female business |
| Zdroj: | The Lancet. 301:391-394 |
| ISSN: | 0140-6736 |
| Popis: | The fasting levels of plasma-triglyceride were increased in nine out of ten primary hypothyroid subjects, and they returned towards normal after thyroxine therapy. In seven thyrotoxic patients, fasting triglyceride levels were low normal and the mean levels did not change after antithyroid therapy. The clearance-rate of an infused triglyceride load showed abnormalities more striking than the changes observed in circulating triglyceride level. The clearance-rate in hypothyroid subjects was low and in the thyrotoxic patients it was either high or normal. After treatment of either state the fractional clearance-rates tended towards normal. There were parallel changes in free-fatty-acid flux. In the hypothyroid subjects, a slow clearance of exogenous triglyceride was associated with low post-heparin lipolytic activity (P.H.L.A.), but in the thyrotoxic subjects the rapid clearance of triglyceride was associated with unexpected low or low normal P.H.L.A. levels. It is suggested that in thyroid disease the tissue clearance of circulating triglycerides may be an important determinant of fasting plasma-triglyceride values. |
| Databáze: | OpenAIRE |
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