Immunoglobulin G subclass levels and antibody responses to the 2009 influenza A (H1N1) monovalent vaccine among human immunodeficiency virus (HIV)-infected and HIV-uninfected adults
| Autor: | Gary Collins, Anuradha Ganesan, D. Faix, Lynn E. Eberly, Timothy Burgess, P. J. Blair, Tahaniyat Lalani, Brian K. Agan, Erik Iverson, Nancy F. Crum-Cianflone, Carolyn Brandt, Gabriel Defang, James H. Maguire, Timothy J. Whitman, Christopher A. Duplessis |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Influenza vaccine Immunology HIV Infections medicine.disease_cause Antibodies Viral Subclass Immunoglobulin G Immune system Influenza A Virus H1N1 Subtype Immunity Antiretroviral Therapy Highly Active Influenza A virus medicine Immunology and Allergy Humans biology virus diseases Original Articles Middle Aged Virology CD4 Lymphocyte Count Vaccination Influenza Vaccines biology.protein Female Antibody |
| Zdroj: | Clinical and experimental immunology. 168(1) |
| ISSN: | 1365-2249 |
| Popis: | Summary Immunoglobulin (Ig)G levels are important for antibody vaccine responses and IgG subclass deficiencies have been associated with severe 2009 influenza A (H1N1) infections. Studies have demonstrated variations in immune responses to the H1N1 vaccine, but the aetiology of this is unknown. We determined the associations between pre-vaccination overall and influenza-specific IgG subclass levels and 2009 H1N1-specific antibody responses post-vaccination (robust versus poor at day 28) stratified by human immunodeficiency virus (HIV) status. Logistic regression models were utilized to evaluate whether pre-vaccination IgG subclass levels were associated with the antibody response generated post-vaccination. We evaluated 48 participants as part of a clinical study who were stratified by robust versus poor post-vaccination immune responses. Participants had a median age of 35 years; 92% were male and 44% were Caucasian. HIV-infected adults had a median CD4 count of 669 cells/mm3, and 79% were receiving highly active anti-retroviral therapy. HIV-infected participants were more likely to have IgG2 deficiency ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|