Coronary arteriography with an oxygenated contrast medium: Cardiac effects in dogs with and without acute ischemic heart failure
| Autor: | Hans Kristian Pedersen, Helge Refsum, E. A. Jacobsen |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Inotrope
medicine.medical_specialty Ringer's Lactate Iohexol Myocardial Infarction Contrast Media Hemodynamics Coronary Disease Coronary Angiography Electrolytes Dogs Left coronary artery Internal medicine medicine.artery Heart rate medicine Animals Radiology Nuclear Medicine and imaging Heart Failure business.industry Oxygenation medicine.disease Oxygen Injections Intra-Arterial Anesthesia Heart failure Ventricular pressure Cardiology Isotonic Solutions business medicine.drug |
| Zdroj: | Academic Radiology. 3:493-499 |
| ISSN: | 1076-6332 |
| DOI: | 10.1016/s1076-6332(96)80009-2 |
| Popis: | Rationale and Objectives. We investigated the possible cardiac effects of oxygen addition to contrast media (CM) during coronary arteriography in dogs that did and did not have ischemic heart failure. Methods. Acute ischemic heart failure was induced by injecting small plastic microspheres into the left coronary artery of 18 dogs. Hemodynamic and electrophysiologic measurements were performed during a single injection before and during heart failure and during a single injection and five rapidly repeated CM injections during heart failure. Iohexol supplemented with electrolytes (iohexol + electrolytes = IPE), oxygenated IPE (IPE+O), Ringer acetate, and oxygenated Ringer acetate were injected into the left coronary artery. Results. Single injections of IPE and IPE+O induced small hemodynamic and electrophysiologic effects. However, repeated injections of IPE and IPE+O increased left ventricular inotropy (maximum value of the first derivative of the left ventricular pressure) by 36% and 39%, reduced heart rate by 7% (for both), and lengthened QT c time (corrected QT interval) by 39 and 38 msec, respectively. A comparison of IPE and IPE+O revealed no statistically significant differences. Conclusion. Although electrolyte addition to nonionic CM may reduce the risk of cardiac complications during coronary arteriography, oxygenation does not seem to significantly further reduce this risk. |
| Databáze: | OpenAIRE |
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