Clinicopathologic study of mixed hepatocellular and cholangiocellular carcinoma: Modes of spreading and choice of surgical treatment by reference to macroscopic type
| Autor: | Katsunori Kawano, Koichiro Tahara, Atsushi Sasaki, Takanori Yoshida, Seigo Kitano, Yu Takeuchi, Masanori Aramaki, Tsuyoshi Ohno |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Carcinoma Hepatocellular medicine.medical_treatment Major histocompatibility complex Metastasis Cholangiocarcinoma Neoplasms Multiple Primary Necrosis Biomarkers Tumor medicine Humans Neoplasm Invasiveness Neoplasm Metastasis Lymph node Aged biology business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease medicine.anatomical_structure Liver Oncology Biliary tract Hepatocellular carcinoma biology.protein Lymph Node Excision Female Surgery Lymphadenectomy alpha-Fetoproteins Hepatectomy Liver cancer business |
| Zdroj: | Journal of Surgical Oncology. 76:37-46 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/1096-9098(200101)76:1<37::aid-jso1007>3.0.co;2-0 |
| Popis: | Background and Objectives Clinicopathologic features and the choice of surgical treatment for mixed hepatocellular and cholangiocellular carcinoma (MHC) remain controversial. Methods We evaluated the clinicopathological features of seven cases of MHC (one autopsied and six surgically resected cases). MHCs were divided into two classes by reference to macroscopic appearance: four were of the single nodular (SN) type and three were of the multinodular (MN) type. Results The mean age of patients and mean preoperative level of serum alpha-fetoprotein were 44.5 years and 56,457 ng/ml for the SN type and 63.7 years and 1,227 ng/ml for the MN type, respectively. Histologically, invasion of the portal vein, the hepatic vein, and the perineural space was found in three, two, and zero cases of SN type tumors and in three, three, and one cases of MN type tumors, respectively. Lymph node metastases were found only in two patients with MN type MHC. Conclusions MHC of the SN type had a pattern of infiltration similar to hepatocellular carcinoma. By contrast, MHC of the MN type resembled intrahepatic cholangiocellular carcinoma. It is suggested that lymphadenectomy might be necessary for treatment of selected MHC, in particular MHC with a multinodular appearance. J. Surg. Oncol. 2001;76:37–46. © 2001 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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