Differentiation and apoptosis of murine neuroblastoma cells N1E115
| Autor: | S.R. Umansky, M.A. Kostenko, R.Y. Gordon, I.I. Kruman, V.I. Popov |
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| Rok vydání: | 1993 |
| Předmět: |
Programmed cell death
Biophysics Apoptosis Cycloheximide Biology In Vitro Techniques Biochemistry chemistry.chemical_compound Mice Neuroblastoma medicine Tumor Cells Cultured Animals Dimethyl Sulfoxide Molecular Biology Neurons Dimethyl sulfoxide Cell Differentiation Cell Biology medicine.disease In vitro Cell biology chemistry Cell culture Immunology DNA fragmentation DNA Damage |
| Zdroj: | Biochemical and biophysical research communications. 191(3) |
| ISSN: | 0006-291X |
| Popis: | The mode and the kinetics of differentiation and death of murine N1E115 neuroblastoma cells induced by dimethyl sulfoxide and other nonspecific factors in vitro were investigated. After morphological differentiation neuroblastoma cells die by apoptosis which is indicated by characteristic morphological features and by internucleosomal DNA fragmentation. Durations of both differentiation and apoptosis are dependent on the nature of stimuli used. Protein synthesis inhibitor cycloheximide does not prevent differentiation and apoptosis of neuroblastoma cells induced by dimethyl sulfoxide and even accelerates both processes. The relationship between cell death and differentiation is discussed. |
| Databáze: | OpenAIRE |
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