The effects of dual and triple combinations of trandolapril, telmisartan, and verapamil on overt proteinuria in the patients with diabetic nephropathy
| Autor: | Bulent Albayrak, Serkan Cerrah, Erdem Çankaya, Yusuf Bilen, Ramazan Cetinkaya |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Trandolapril
Adult Male medicine.medical_specialty Indoles Adolescent Urology Renal function lcsh:Medicine Angiotensin-Converting Enzyme Inhibitors Blood Pressure Benzoates Nephropathy Diabetic nephropathy Young Adult Internal medicine Medicine Humans Diabetic Nephropathies Telmisartan Aged Proteinuria business.industry lcsh:R General Medicine Middle Aged medicine.disease Blood pressure Endocrinology Verapamil Benzimidazoles Drug Therapy Combination Female medicine.symptom business medicine.drug |
| Zdroj: | Saudi Journal of Kidney Diseases and Transplantation, Vol 27, Iss 3, Pp 512-518 (2016) |
| ISSN: | 1319-2442 |
| Popis: | Diabetic nephropathy (DN) is one of the most important causes of the end-stage renal failure and its prevalence is found to be increasing. The presence of hypertension and progressive proteinuria is among the important findings. In this study, the effects of double and triple combinations of trandolapril, telmisartan, and verapamil on proteinuria were investigated in diabetic patients with nephropathy. Seventy-eight patients (mean age: 56.11 ± 11.26 years; 47 females and 31 males) with overt proteinuria and DN were included in this study. The patients were divided into four groups: Group I (n: 18, trandolapril + telmisartan), Group II (n: 20, trando- lapril + verapamil), Group III (n: 20, trandolapril +telmisartan + verapamil), and Group IV (n: 20, telmisartan + verapamil). At the end of a three-month therapy, within and between group compa- risons were done about the effects of the use of double or triple drug combinations on proteinuria, glomerular filtration rate (GFR), electrolytes, serum albumin, low-density lipoprotein (LDL)- cholesterol, and HbA1C. There was no significant difference among groups in terms of age, gender, diabetes duration, body mass index, and retinopathy frequency. The decreases in protei- nuria and mean arterial blood pressure (MABP) were significant in all groups. The decrease in proteinuria was independent of the decrease in MABP [the reduction rate in proteinuria was 39% (P |
| Databáze: | OpenAIRE |
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