Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii
| Autor: | Ruth Dorn, Jun Ma, Ilya Raskin, Moul Dey, Hui Yang, Peter E. Lipsky, Reneta Pouleva, Edward J. Kennelly, Alexander Poulev |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.drug_class
Tripterygium medicine.medical_treatment Anti-Inflammatory Agents Plant Science Horticulture Pharmacology Pharmacognosy Chemical Fractionation Biochemistry Anti-inflammatory Cell Line chemistry.chemical_compound Mice medicine Animals Molecular Biology Nuclear Magnetic Resonance Biomolecular Lignan biology Plant Extracts Immunosuppression Biological activity General Medicine Triptolide Phenanthrenes biology.organism_classification medicine.disease chemistry Rheumatoid arthritis Epoxy Compounds Tripterygium wilfordii Diterpenes Immunosuppressive Agents |
| Zdroj: | Phytochemistry. 68(8) |
| ISSN: | 0031-9422 |
| Popis: | The extract of Tripterygium wilfordii Hook F. (TwHF), which showed anti-inflammatory and immunosuppressive activities in human clinical trials for rheumatoid arthritis, was subjected to the activity-guided fractionation and spectroscopic characterization of bioactives. A tetrahydrofuran lignan, tripterygiol (1), and eight known compounds, all capable of suppressing pro-inflammatory gene expression were identified. Most of the pharmacological activity of the extract can be attributed to triptolide, its most abundant and active component, with some contribution from tripdiolide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect