Electro-responsive films containing voltage responsive gated mesoporous silica nanoparticles grafted onto PEDOT-based conducting polymer
| Autor: | Ramón Martínez-Máñez, Alba García-Fernández, María D. Marcos, Javier Monreal-Trigo, Miguel Alcañiz, Beatriz Lozano-Torres, Juan F. Blandez, Jorge E. Collazos-Castro, Juan Soto, Félix Sancenón |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Voltage-gated MSNs
Materials science Biocompatibility Polymers Conducting polymers Pharmaceutical Science Nanoparticle 02 engineering and technology Electro-responsive TECNOLOGIA ELECTRONICA 03 medical and health sciences chemistry.chemical_compound QUIMICA ORGANICA PEDOT:PSS BIOQUIMICA Y BIOLOGIA MOLECULAR Rhodamine B Humans Controlled release Conducting polymers Controlled release Electro-responsive PEDOT Voltage-gated MSNs PEDOT 030304 developmental biology Conductive polymer chemistry.chemical_classification 0303 health sciences QUIMICA INORGANICA Polymer Mesoporous silica Bridged Bicyclo Compounds Heterocyclic Silicon Dioxide 021001 nanoscience & nanotechnology chemistry Chemical engineering Saturated calomel electrode Nanoparticles 0210 nano-technology Porosity HeLa Cells |
| Zdroj: | JOURNAL OF CONTROLLED RELEASE r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Centro de Investigación Principe Felipe (CIPF) RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) |
| ISSN: | 0168-3659 |
| Popis: | [EN] The characteristics and electromechanical properties of conductive polymers together to their biocompatibility have boosted their application as a suitable tool in regenerative medicine and tissue engineering. However, conducting polymers as drug release materials are far from being ideal. A possibility to overcome this drawback is to combine conducting polymers with on-command delivery particles with inherent high-loading capacity. In this scenario, we report here the preparation of conduction polymers containing gated mesoporous silica nanoparticles (MSN) loaded with a cargo that is delivered on command by electro-chemical stimuli increasing the potential use of conducting polymers as controlled delivery systems. MSNs are loaded with Rhodamine B (Rh B), anchored to the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly[(4-styrenesulfonic acid)-co-(maleic acid)], functionalized with a bipyridinium derivative and pores are capped with heparin (P3) by electrostatic interactions. P3 releases the entrapped cargo after the application of ¿640 mV voltage versus the saturated calomel electrode (SCE). Pore opening in the nanoparticles and dye delivery is ascribed to both (i) the reduction of the grafted bipyridinium derivative and (ii) the polarization of the conducting polymer electrode to negative potentials that induce detachment of positively charged heparin from the surface of the nanoparticles. Biocompatibility and cargo release studies were carried out in HeLa cells cultures. Alba Garcia-Fernandez, Beatriz Lozano-Torres contributed equally to this work. A. Garcia-Fernandez and B. Lozano-Torres are grateful to the "Ministerio de Economia y Competitividad" of the Spanish Government for her PhD fellowships. J. F. Blandez thanks the "Universitat Politecnica de Valencia" for his postdoctoral fellowship (PAID-10-17). The authors thank to the Spanish Government (Projects RTI2018-100910-B-C41 and RTI2018-101599-B-C22 (MCUI/AEI/FEDER, EU)) and the Generalitat Valencia (Project PROMETEO2018-024) for support. |
| Databáze: | OpenAIRE |
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