Alzheimer's disease as a defect of neuronal autotrophism: a hypothetical analogy with amateur radio operation
| Autor: | T.-K. Baik, Roger A. Brumback, R.W. Leech |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Neurofilament
Models Neurological Apoptosis Protein filament Synapse Amyloid beta-Protein Precursor Degenerative disease Alzheimer Disease medicine Amyloid precursor protein Animals Humans Secretion Neurons biology Hobbies Neurofibrillary Tangles General Medicine medicine.disease Radio medicine.anatomical_structure biology.protein Neuron Alzheimer's disease Neuroscience Signal Transduction |
| Zdroj: | Medical hypotheses. 50(6) |
| ISSN: | 0306-9877 |
| Popis: | Amyloid precursor protein appears to be a signaling protein that plays a role in neuronal autotrophism, indicating integrity of the nerve terminal and synapse. Analogous to amateur radio operation with a damaged antenna in which further attempts to improve signal propagation can result in damage to the radio equipment, abnormal signaling by the secreted amyloid precursor protein stimulates compensatory metabolic activity in the neuron that ultimately leads to paired helical filament formation (neurofibrillary tangles) and further neuronal dysfunction and death. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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