Factors associated with IgG levels in adults with IgG subclass deficiency
| Autor: | Jackson C. Barton, James C. Barton, Luigi F. Bertoli, Ronald T. Acton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Allergy Immunology IgG subclass deficiency Background factors Gastroenterology Subclass Autoimmune Diseases Atopy Seroepidemiologic Studies Internal medicine parasitic diseases medicine Humans In patient IgG Deficiency Aged business.industry Research IgG1 IgG2 IgG3 Igg subclasses RC581-607 Middle Aged medicine.disease United States Immunoglobulin Isotypes Immunoglobulin G Female Autoimmune condition Immunologic diseases. Allergy business |
| Zdroj: | BMC Immunology BMC Immunology, Vol 22, Iss 1, Pp 1-11 (2021) |
| ISSN: | 1471-2172 |
| Popis: | Background Factors associated with IgG levels in adults with IgG subclass deficiency (IgGSD) are incompletely understood. We studied adults with IgGSD with subnormal IgG1 only, subnormal IgG1/IgG3, or subnormal IgG3 only without other subnormal IgG subclasses, IgA, or IgM. We compiled: age; sex; autoimmune condition(s) (AC); atopy; IgG, IgG subclasses, IgA, IgM; IgGsum (IgG1 + IgG2 + IgG3 + IgG4); and D (percentage difference between IgGsum and IgG). We compared attributes of patients with/without subnormal IgG ( Results There were 39 patients with subnormal IgG1 only (89.7% women), 53 with subnormal IgG1/IgG3 (88.7% women), and 115 with subnormal IgG3 only (91.3% women). Fifteen patients (38.5%) and 32 patients (60.4%) in the respective subnormal IgG1 subclass groups had subnormal IgG. Attributes of patients with/without IgG p = 0.0484). Mean/median IgG1 and IgG2 were significantly lower in patients with IgG p p p Conclusions We conclude that both IgG1 and IgG2 are major determinants of IgG in patients with subnormal IgG1, combined subnormal IgG1/IgG3, or subnormal IgG3 and that in patients with subnormal IgG1 or combined subnormal IgG1/IgG3, median IgG2 levels are significantly lower in those with IgG |
| Databáze: | OpenAIRE |
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