Prolactin as a link between behavioral and immune differences between the Roman rat lines
| Autor: | Michel Le Moal, Josette Dulluc, Pierre Mormède, Nathalie Castanon |
|---|---|
| Přispěvatelé: | Unité mixte de recherche neurobiologie intégrative, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), ProdInra, Migration |
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Corticotropin-Releasing Hormone [SDV]Life Sciences [q-bio] medicine.medical_treatment Radioimmunoassay Experimental and Cognitive Psychology Motor Activity Biology Natural killer cell 03 medical and health sciences Behavioral Neuroscience Basal (phylogenetics) 0302 clinical medicine Immune system Adrenocorticotropic Hormone Species Specificity Internal medicine medicine Animals Endocrine system Aldosterone ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Behavior Animal Immunity Classical conditioning CRF Prolactin Rats [SDV] Life Sciences [q-bio] Killer Cells Natural Steroid hormone Endocrinology medicine.anatomical_structure RAT Female Corticosterone 030217 neurology & neurosurgery Psychoneuroimmunology |
| Zdroj: | Physiology and Behavior Physiology and Behavior, Elsevier, 1992, 51, pp.1235-1241 HAL |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/0031-9384(92)90314-r |
| Popis: | Roman high (RHA)- and low (RLA)-avoidance rats are two lines of Wistar rats genetically selected on the basis of their active avoidance behavior in a shuttle-box. They also differ in several other behavioral responses, such as their locomotor activity in novel environments (open-field, circular corridor), with the RHA rats being more active than the RLA animals, as well as in endocrine reactivity and immune functions. These experiments were designed to investigate further the neuroendocrine characteristics of these animals as a possible link between the brain and immune functions. Despite the marked behavioral and immune differences observed, no between-lines variation could be found in basal hypothalamo-pituitary-adrenocortical axis activity or in its responses to different protocols of novel environment stress, or after corticotropin-releasing factor (CRF) challenge. On the other hand, stimulated prolactin levels were higher in the low avoidance line. These results exclude the pituitary-adrenocortical axis and suggest prolactin as a link between behavioral and immune differences between the Roman lines. Moreover, these results indicate that these rats may be an excellent model for the study of the relationships between the brain and the immune system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|