Influence of radiation dose in computed tomography on antioxidant enzyme activity in rabbit erythrocytes
| Autor: | R Nikola Tatalovic, F Olivera Ciraj-Bjelac, S Zorana Orescanin-Dusic, L Aleksandra Nikolic-Kokic, B Marko Mitrovic, P Dusko Blagojevic, E Nikola Krstic, V Mirjana Lazarevic-Macanovic |
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| Rok vydání: | 2017 |
| Předmět: |
antioxidant enzyme
Antioxidant medicine.medical_treatment rabbit Computed tomography Rabbit Pharmacology Ct dose index Medicine lcsh:Nuclear and particle physics. Atomic energy. Radioactivity Irradiation Safety Risk Reliability and Quality chemistry.chemical_classification biology medicine.diagnostic_test business.industry Antioxidant enzyme Radiation dose computed tomography Rabbit (nuclear engineering) CT dose index Enzyme assay Erythrocyte Enzyme Nuclear Energy and Engineering chemistry biology.protein lcsh:QC770-798 erythrocyte business |
| Zdroj: | Nuclear Technology and Radiation Protection Nuclear technology and radiation protection Nuclear Technology and Radiation Protection, Vol 32, Iss 4, Pp 342-349 (2017) |
| ISSN: | 1452-8185 1451-3994 |
| DOI: | 10.2298/ntrp1704342m |
| Popis: | The objective of this study was to assess the radiation dose in computed tomography examinations of rabbits using different examination protocols and to correlate these values with the activity of antioxidant enzymes in their red blood cells following irradiation. The presented results revealed that a single, routine computed tomography scan exposure led to a different response of the activity of antioxidant enzymes in red blood cells regarding both dose and time. The results indicate that there is a dose threshold that is about 25 mGy. Doses below that level do not produce any significant changes in the level of antioxidant enzymes activity. On the other hand, the level just above that threshold had a significant impact on the antioxidant defence, but in a relatively short time period (2 hours after exposure), compared to the higher dose that requires a longer adaptive period. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 173014: Molecular mechanisms of redox signalling in homeostasis: adaptation and pathology] |
| Databáze: | OpenAIRE |
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