Maternal consumption of high-fat diet and grape juice modulates global histone H4 acetylation levels in offspring hippocampus: A preliminary study
| Autor: | Laura Reck Cechinel, Alexandre Silva de Mello, Marina Rocha Frusciante, Cláudia Funchal, Viviane Rostirola Elsner, Luciana Kneib Gonçalves, Caroline Dani, Ivy Reichert Vital da Silva |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Offspring Gene Expression Biology Diet High-Fat Hippocampus Histone H4 Histones 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Lactation medicine Hippocampus (mythology) Animals Epigenetics Rats Wistar General Neuroscience Body Weight Acetylation medicine.disease Temporal Lobe Purple Grape Juice 030104 developmental biology Endocrinology medicine.anatomical_structure Biochemistry Prenatal Exposure Delayed Effects Female Protein Processing Post-Translational 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience letters. 661 |
| ISSN: | 1872-7972 |
| Popis: | This study aimed to investigate the impact of maternal consumption of a hyperlipid diet and grape juice on global histone H4 acetylation levels in the offsprinǵs hippocampus at different stages of development. During pregnancy and lactation of offspring, dams were divided into 4 groups: control diet (CD), high-fat diet (HFD), control diet and purple grape juice (PGJCD) and purple grape juice and high-fat diet (PGJHFD). Male Wistar rats were euthanized at 21days of age (PN21, adolescents) and at 50days of age (PN50, adults). The maternal consumption of grape juice increased global histone H4 acetylation levels in hippocampus of adolescents pups (PN21), an indicative of enhanced transcriptional activity and increased gene expression. On the other hand, the maternal high-fat diet diminished significantly this epigenetic marker in the adult phase (PN50), suggesting gene silencing. These preliminary findings demonstrated that the maternal choices are able to induce changes on histone H4 acetylation status in hippocampus of the offspring, which may modulate the expression of specific genes. Interestingly, this response occurs in an age and stimuli-dependent manner and strongly reinforce the importance of maternal choices during gestation. |
| Databáze: | OpenAIRE |
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