Impact of 1-Hour Bundle Achievement in Septic Shock
| Autor: | Hyunggoo Kang, Donghee Son, Gil Joon Suh, Sung Hyuk Choi, Byuk Sung Ko, Yoo Seok Park, Won Young Kim, Tae Gun Shin, Seung Mok Ryoo, Kyuseok Kim, Han Sung Choi, Sung Phil Chung, Tae Ho Lim, You Hwan Jo, Woon Yong Kwon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Resuscitation
emergency department lcsh:Medicine 030204 cardiovascular system & hematology Logistic regression Article Sepsis sepsis 03 medical and health sciences 0302 clinical medicine Medicine In patient 030212 general & internal medicine business.industry Septic shock lcsh:R General Medicine Odds ratio Emergency department medicine.disease 1-h bundle mortality Bundle Anesthesia outcome septic shock business |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 3 Journal of Clinical Medicine, Vol 10, Iss 527, p 527 (2021) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10030527 |
| Popis: | This study aimed to address the impact of 1-hr bundle achievement on outcomes in septic shock patients. Secondary analysis of multicenter prospectively collected data on septic shock patients who had undergone protocolized resuscitation bundle therapy at emergency departments was conducted. In-hospital mortality according to 1-h bundle achievement was compared using multivariable logistic regression analysis. Patients were also divided into 3 groups according to the time of bundle achievement and outcomes were compared to examine the difference in outcome for each group over time: group 1 (≤1 h reference), group 2 (1–3 h) and group 3 (3–6 h). In total, 1612 patients with septic shock were included. The 1-h bundle was achieved in 461 (28.6%) patients. The group that achieved the 1-h bundle did not show a significant difference in in-hospital mortality compared to the group that did not achieve the 1-h bundle on multivariable logistic regression analysis (< 1 vs. > 1 h) (odds ratio = 0.74, p = 0.091). However, 3- and 6- h bundle achievements showed significantly lower odds ratios of in-hospital mortality compared to the group that did not achieve the bundle (< 3 vs. > 3 h, < 6 vs. > 6 h, odds ratio = 0.604 and 0.458, respectively). There was no significant difference in in-hospital mortality over time for group 2 and 3 compared to that of group 1. One-hour bundle achievement was not associated with improved outcomes in septic shock patients. These data suggest that further investigation into the clinical implications of 1-h bundle achievement in patients with septic shock is warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |