Associations between maternal physical activity in early and late pregnancy and offspring birth size

Autor: Fionnuala M. McAuliffe, Tanja G. M. Vrijkotte, Eileen C O'Brien, Soren Brage, Dana Dabelea, Paul Burton, K Kordas, Silvia Pastorino, Sarah Crozier, Leanne K. Küpers, Paul Scherer, Wojciech Hanke, Katrien Wijndaele, Hazel Inskip, Eva Corpeleijn, Tom R.P. Bishop, Charles Agyemang, Aileen Kennedy, Katherine A. Sauder, Donal J. O’Gorman, Mohammad Hadi Zafarmand, Nicholas J. Wareham, Ken K. Ong, Gernot Desoye, Rebecca Wilson, Cyrus Cooper, Sjurdur F. Olsen, Charlotta Granström, Kinga Polańska
Přispěvatelé: ACS - Atherosclerosis & ischemic syndromes, Epidemiology and Data Science, Public and occupational health, APH - Personalized Medicine, APH - Global Health, ARD - Amsterdam Reproduction and Development, APH - Health Behaviors & Chronic Diseases, APH - Aging & Later Life, APH - Methodology, ACS - Diabetes & metabolism, Bishop, Thomas [0000-0002-3407-2526], Brage, Soren [0000-0002-1265-7355], Scherer, Paul [0000-0002-2240-7501], Wijndaele, Katrien [0000-0003-2199-7981], Wareham, Nicholas [0000-0003-1422-2993], Ong, Kenneth [0000-0003-4689-7530], Apollo - University of Cambridge Repository, Nofer Institute of Occupational Medicine, Lifestyle Medicine (LM), Reproductive Origins of Adult Health and Disease (ROAHD)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
physical activity
large for gestational age
Fetal Macrosomia
Cohort Studies
0302 clinical medicine
Risk Factors
Pregnancy
LGA
small-for-gestational age
macrosomia
10. No inequality
education.field_of_study
030219 obstetrics & reproductive medicine
Obstetrics and Gynecology
Gestational age
3. Good health
Gestational diabetes
Adipose Tissue
Pregnancy Trimester
Second
Infant
Small for Gestational Age
Gestation
Female
pregnancy
Adult
Birth weight
Pregnancy Trimester
Third
Population
Article
03 medical and health sciences
Young Adult
medicine
Humans
Obesity
education
Biology
Exercise
SGA
business.industry
Body Weight
Infant
Newborn
birth weight
Anthropometry
Overweight
Protective Factors
medicine.disease
Pregnancy Complications
Diabetes
Gestational
Pregnancy Trimester
First
large-for-gestational age
Linear Models
Small for gestational age
business
Energy Metabolism
Demography
Zdroj: BJOG, 126(4), 459-470. Wiley-Blackwell
BJOG : an international journal of obstetrics and gynaecology
BJOG : An International Journal of Obstetrics and Gynaecology, 126(4), 459-470. Wiley
Articles
ISSN: 1471-0528
1470-0328
Popis: Objective: Evidence on the impact of leisure time physical activity (LTPA) in pregnancy on birth size is inconsistent. We aimed to examine the association between LTPA during early and late pregnancy and newborn anthropometric outcomes.Design: Individual level meta‐analysis, which reduces heterogeneity across studies.Setting: A consortium of eight population‐based studies (seven European and one US) comprising 72 694 participants.Methods: Generalised linear models with consistent inclusion of confounders (gestational age, sex, parity, maternal age, education, ethnicity, BMI, smoking, and alcohol intake) were used to test associations between self‐reported LTPA at either early (8–18 weeks gestation) or late pregnancy (30+ weeks) and the outcomes. Results were pooled using random effects meta‐analyses.Main outcome measures: Birth weight, large‐for‐gestational age (LGA), macrosomia, small‐for‐gestational age (SGA), % body fat, and ponderal index at birth.Results: Late, but not early, gestation maternal moderate to vigorous physical activity (MVPA), vigorous activity, and LTPA energy expenditure were modestly inversely associated with BW, LGA, macrosomia, and ponderal index, without heterogeneity (all: I2 = 0%). For each extra hour/week of MVPA, RR for LGA and macrosomia were 0.97 (95% CI: 0.96, 0.98) and 0.96 (95% CI: 0.94, 0.98), respectively. Associations were only modestly reduced after additional adjustments for maternal BMI and gestational diabetes. No measure of LTPA was associated with risk for SGA.Conclusions: Physical activity in late, but not early, pregnancy is consistently associated with modestly lower risk of LGA and macrosomia, but not SGA.Tweetable abstract: In an individual participant meta‐analysis, late pregnancy moderate to vigorous physical activity modestly reduced birth size outcomes.
Databáze: OpenAIRE
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