Posttraumatic stress disorder symptoms in patients with acute myeloid leukemia
| Autor: | Madeleine Elyze, Jason A. Webb, Jillian Gustin, Areej El-Jawahri, Dagny M. Vaughn, Lara Traeger, Hermioni L. Amonoo, Selina M. Luger, Nina O'Connor, Andrew M. Brunner, Thomas W. LeBlanc, Annemarie D. Jagielo, Bhavana Bhatnagar, Amir T. Fathi, Regina M. Longley, Gabriela S. Hobbs, Nora Horick, Alison R. Kavanaugh |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Coping (psychology) Population Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine mental disorders Adaptation Psychological Medicine Humans 030212 general & internal medicine education education.field_of_study Acute leukemia business.industry Traumatic stress Hypervigilance Hospitalization Distress Leukemia Myeloid Acute Oncology 030220 oncology & carcinogenesis Psychological well-being Quality of Life medicine.symptom business |
| Zdroj: | CancerReferences. 127(14) |
| ISSN: | 1097-0142 |
| Popis: | Background Patients with acute myeloid leukemia (AML) receiving intensive chemotherapy face a life-threatening illness, isolating hospitalization, and substantial physical and psychological symptoms. However, data are limited regarding risk factors of posttraumatic stress disorder (PTSD) symptoms in this population. Methods The authors conducted a secondary analysis of data from 160 patients with high-risk AML who were enrolled in a supportive care trial. The PTSD Checklist-Civilian Version was used to assess PTSD symptoms at 1 month after AML diagnosis. The Brief COPE and the Functional Assessment of Cancer Therapy-Leukemia were to assess coping and quality of life (QOL), respectively. In addition, multivariate regression models were constructed to assess the relation between PTSD symptoms and baseline sociodemographic factors, coping, and QOL. Results Twenty-eight percent of patients reported PTSD symptoms, describing high rates of intrusion, avoidance, and hypervigiliance. Baseline sociodemographic factors significantly associated with PTSD symptoms were age (B = -0.26; P = .002), race (B = -8.78; P = .004), and postgraduate education (B = -6.30; P = .029). Higher baseline QOL (B = -0.37; P ≤ .001) and less decline in QOL during hospitalization (B = -0.05; P = .224) were associated with fewer PTSD symptoms. Approach-oriented coping (B = -0.92; P = .001) was associated with fewer PTSD symptoms, whereas avoidant coping (B = 2.42; P ≤ .001) was associated with higher PTSD symptoms. Conclusions A substantial proportion of patients with AML report clinically significant PTSD symptoms 1 month after initiating intensive chemotherapy. Patients' baseline QOL, coping strategies, and extent of QOL decline during hospitalization emerge as important risk factors for PTSD, underscoring the need for supportive oncology interventions to reduce the risk of PTSD in this population. |
| Databáze: | OpenAIRE |
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