Preventive brain radio-chemotherapy alters plasticity associated metabolite profile in the hippocampus but seems to not affect spatial memory in young leukemia patients

Autor: Kai F. Loewenbrück, Robby Schönfeld, Rüdiger von Kummer, Alexander Storch, Moritz D. Brandt, Markus Schaich, Annett Werner, Markus Donix, Bernd Leplow, Martin Bornhäuser, Kalina Brandt
Rok vydání: 2015
Předmět:
Male
drug effects [Dentate Gyrus]
drug effects [Hippocampus]
Magnetic Resonance Spectroscopy
Nerve net
Hippocampus
metabolism [Hippocampus]
Pilot Projects
drug effects [Neurogenesis]
Hippocampal formation
Adult neurogenesis
Behavioral Neuroscience
metabolism [Leukemia]
drug effects [Neuronal Plasticity]
pathology [Leukemia]
pathology [Neurons]
virtual water maze
Longitudinal Studies
Spatial Memory
Original Research
Neurons
Leukemia
Neuronal Plasticity
radiation effects [Dentate Gyrus]
Brain Neoplasms
Neurogenesis
metabolism [Dentate Gyrus]
Human brain
proton magnetic resonance spectroscopy
radiation effects [Spatial Memory]
metabolism [Brain Neoplasms]
radiation effects [Hippocampus]
medicine.anatomical_structure
metabolism [Neurons]
drug effects [Spatial Memory]
radiotherapy [Leukemia]
Female
Psychology
prevention & control [Brain Neoplasms]
drug therapy [Leukemia]
Adult
pathology [Brain Neoplasms]
drug effects [Maze Learning]
radiation effects [Neurons]
choline
Neuroplasticity
Biological neural network
medicine
drug effects [Neurons]
Humans
ddc:610
human
Maze Learning
Dentate gyrus
Dentate Gyrus
radiation effects [Neurogenesis]
Nerve Net
Neuroscience
Zdroj: Brain and Behavior
Brain and behavior 5(9), n/a-n/a (2015). doi:10.1002/brb3.368
ISSN: 2162-3279
DOI: 10.1002/brb3.368
Popis: Background Neuronal plasticity leading to evolving reorganization of the neuronal network during entire lifespan plays an important role for brain function especially memory performance. Adult neurogenesis occurring in the dentate gyrus of the hippocampus represents the maximal way of network reorganization. Brain radio-chemotherapy strongly inhibits adult hippocampal neurogenesis in mice leading to impaired spatial memory. Methods To elucidate the effects of CNS radio-chemotherapy on hippocampal plasticity and function in humans, we performed a longitudinal pilot study using 3T proton magnetic resonance spectroscopy (1H-MRS) and virtual water-maze-tests in 10 de-novo patients with acute lymphoblastic leukemia undergoing preventive whole brain radio-chemotherapy. Patients were examined before, during and after treatment. Results CNS radio-chemotherapy did neither affect recall performance in probe trails nor flexible (reversal) relearning of a new target position over a time frame of 10 weeks measured by longitudinal virtual water-maze-testing, but provoked hippocampus-specific decrease in choline as a metabolite associated with cellular plasticity in 1H-MRS. Conclusion Albeit this pilot study needs to be followed up to definitely resolve the question about the functional role of adult human neurogenesis, the presented data suggest that 1H-MRS allows the detection of neurogenesis-associated plasticity in the human brain.
Databáze: OpenAIRE
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