| Popis: |
Rotavirus (RV) is the main cause of acute gastroenteritis (GE) in children under 5 years of age with a high incidence between the ages of 6 and 23 months. After one year of introduction in the EPV in Cameroon, it was interesting to evaluate the vaccine efficacy of Rotarix in the field. To this end, we set ourselves the objective of evaluating the field efficacy of Rotarix® in children aged 2 to 24 months in selected District Hospitals of the Centre-Cameroon Region. We conducted a case-control study in children aged 2 to 24 months ; 77 subjects were included in our study and stool samples were collected from March to August of 2015. Antigenic detection of Rotavirus was carried out by an immunochromatographic test (rapid test). We had a sex ratio of 1.3 in favour of the male sex ; the age groups most represented were those of 2 to 6 months and 18-24 months, i.e. 28.6% each ; 50 subjects had been vaccinated (exposure to the protection factor) with 1 positive case and 27 non-vaccinated with 6 positive cases, i.e. a vaccination coverage of 64.94%. Of the subjects found positive, those in the 2-12 months age group represented 42.9%, compared to 57.1%. For vaccine efficacy, statistical analysis was performed using Epi info software version 7.1.3.0 and the odds ratio was estimated to be 0.0714 with 95% CI bounds 0.0081; 0.6305. The resulting field efficacy according to the WHO proposed formula is 92.86% with 95% bounds of CI 36.95% to 99.19%. These results should be complemented by similar studies for each region of the country to determine the field efficacy of Rotarix in Cameroon. |
