Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats
| Autor: | Linyu Wei, Chaokun Li, Hou Ruanling, Guo-hong Wang, Hua Han, Dongliang Li, Xin-juan Li |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Physiology Hippocampal formation Hippocampus Neuroprotection Rats Sprague-Dawley Pregnancy Internal medicine medicine Animals Hypoxia Progesterone Neurons Glucose Transporter Type 1 Glucose Transporter Type 3 biology business.industry General Neuroscience Glucose transporter General Medicine Hypoxia (medical) medicine.disease Rats Glucose Endocrinology Animals Newborn Reperfusion Injury biology.protein Female Original Article GLUT1 medicine.symptom business Reperfusion injury GLUT3 |
| Zdroj: | Neuroscience Bulletin. 29:287-294 |
| ISSN: | 1995-8218 1673-7067 |
| DOI: | 10.1007/s12264-013-1298-y |
| Popis: | Progesterone is an efficient candidate for treating stroke and traumatic brain damage. The current study was designed to investigate the effects of progesterone on glucose transporter proteins (GLUT1 and GLUT3) during hypoxic-ischemic injury in a neonatal rat model. We demonstrated strong staining for GLUT1 in the walls of blood vessels and GLUT3 immunoreactivity in hippocampal neurons after hypoxiaischemia. Hypoxia-ischemia elevated GLUT1 and GLUT3 at both the mRNA and protein levels in the hippocampus, and pre-treatment with progesterone (8 mg/kg) further enhanced their accumulation until 24 h after hypoxic-ischemic injury. These results showed that progesterone treatment induced the accumulation of both GLUT1 and GLUT3 transporters, and an energy-compensation mechanism may be involved in the neuroprotective effect of progesterone during hypoxic-ischemic injury after cerebral ischemic attacks. |
| Databáze: | OpenAIRE |
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