Cardiocirculatory arrest with hypothermia. Experimental study
| Autor: | F Culicchia, Alfredo Puca, Joseph M. Zabramski, R F Spetzler |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Neurology medicine.drug_class Dermatology Motor Activity Body Temperature Brain ischemia Cognition Hypothermia Induced medicine Animals Neuroradiology Behavior Animal business.industry General Neuroscience Extracorporeal circulation Brain Electroencephalography General Medicine Brain protection Hypothermia medicine.disease Heart Arrest Surgery Psychiatry and Mental health Barbiturate Anesthesia Neurology (clinical) Neurosurgery medicine.symptom business Papio |
| Zdroj: | The Italian Journal of Neurological Sciences. 12:49-55 |
| ISSN: | 1590-3478 0392-0461 |
| Popis: | Direct surgical attack on intracranial malformations of great complexity may be facilitated by complete cardiocirculatory arrest under hypothermia. To improve the technical aspects of this procedure and to determine the optimum depth of hypothermia, the duration of arrest that can be tolerated, and the role of barbiturate brain protection, we conducted an experimental study on 11 baboons. Arrest lasted for 45 or 90 minutes at a brain temperature of 12 degrees C. The animals were assessed by clinical, neuroradiological and necropsy examination. All 4 animals subjected to 45 minutes arrest made a good clinical recovery while 3 of the 7 subjected to 90 minutes arrest presented thromboembolic complications. Strict heparinization in the last 2 animals solved these problems. The findings of this study may help to make the procedure safer for clinical use. |
| Databáze: | OpenAIRE |
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