Dyslipidaemic changes in women with subclinical hypothyroidism
| Autor: | K.N. Poornima, K Dillara, N. Karthick, A S Subhasini |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
endocrine system dyslipidaemia endocrine system diseases Clinical Biochemistry lcsh:Medicine Physiology Diabetes mellitus Internal medicine medicine Euthyroid Risk factor Subclinical infection medicine.diagnostic_test business.industry lcsh:R Thyroid Case-control study General Medicine medicine.disease Obesity subclinical hypothyroidism lipid profile Endocrinology medicine.anatomical_structure lipids (amino acids peptides and proteins) Original Article Lipid profile business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 7, Iss 10, Pp 2122-2125 (2013) |
| ISSN: | 2249-782X |
| Popis: | Background: In overt hypothyroidism, many lipid abnormalities have been documented. This study was intended to demonstrate the levels of lipid in women with subclinical hypothyroidism (SH). Material and Methods: This was a case control study which was done at referral Centre in Chennai. Women with subclinical hypothyroidism and euthyroid women attending our master health checkup clinic were enrolled in this study.Their lipid profile, fasting blood sugar, T3,T4 and TSH levels were measured. In subclinical hypothyroidism, various parameters were compared. Results: Thirty euthyroid and 30 age matched subclinical hypothyroid women were enrolled in this study. There were significant dyslipidaemic changes is SH women as compared to euthyroid controls. Serum total cholesterol and triglyceride levels were significantly higher as compared to those in controls. LDL levels were higher is SH women, but did not reach statistical significance and lower levels of HDL were noticed in SH subjects as compared to those in euthyroid women. A positive association was also reported between serum TSH and lipid parameters in our study group. Conclusion: SH, the earliest form of thyroid failure, has negative metabolic effects on the affected subjects.SH could be one of the causes of secondary hyperlipidaemia and should be viewed as an independent risk factor for atherosclerosis, along with obesity, hypertension, diabetes, etc. |
| Databáze: | OpenAIRE |
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