Role of aberrant IgG glycosylation in the pathogenesis of inflammatory bowel disease
| Autor: | Yoshihiro Kamada, Tetsuo Takehara, Eiji Miyoshi, Hironobu Fujii, Shinichiro Shinzaki, Hideki Iijima |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adoptive cell transfer Glycosylation Galectins Clinical Biochemistry Biology Inflammatory bowel disease Pathogenesis Mice 03 medical and health sciences chemistry.chemical_compound Immune system Crohn Disease medicine Animals Humans Intestinal Mucosa Immunity Mucosal Galectin Glycobiology Glycosyltransferases Igg glycosylation medicine.disease digestive system diseases Disease Models Animal 030104 developmental biology Carbohydrate Sequence chemistry Immunoglobulin G Immunology Colitis Ulcerative Biomarkers |
| Zdroj: | PROTEOMICS - Clinical Applications. 10:384-390 |
| ISSN: | 1862-8346 |
| Popis: | The intestine is one of the most important organs associated with the immune system. It is thought that disruption of intestinal immunity causes inflammatory bowel disease (IBD). Recent advances in immune glycobiology have provided novel insights into many human diseases. For example, studies of glycosylation remodeling in mice have underscored the importance of oligosaccharides in the pathogenesis of IBD. Furthermore, aberrant glycosylation of IgG is a good serum marker of IBD activity. In this review, we examine current understanding of the role of aberrant glycosylation in the pathogenesis of IBD in terms of our original data and recent reports. |
| Databáze: | OpenAIRE |
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