Clinical drug therapies and biologicals currently used or in clinical trial to treat COVID-19
| Autor: | Colin A. Bill, Rory J. Malek, Charlotte M. Vines |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) media_common.quotation_subject Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RM1-950 Review Antiviral Agents Monoclonals Pandemic medicine Animals Humans Clinical efficacy Intensive care medicine media_common Pharmacology Biological Products Clinical Trials as Topic business.industry SARS-CoV-2 Public health Immunity COVID-19 General Medicine COVID-19 Drug Treatment Clinical trial Vaccination Anti-viral Treatment Outcome Protease inhibitor Therapeutics. Pharmacology Anti-inflammatory business |
| Zdroj: | Biomedicine & Pharmacotherapy Biomedicine & Pharmacotherapy, Vol 144, Iss, Pp 112276-(2021) |
| ISSN: | 1950-6007 0753-3322 |
| Popis: | The potential emergence of SARS-CoV-2 variants capable of escaping vaccine-generated immune responses poses a looming threat to vaccination efforts and will likely prolong the duration of the COVID-19 pandemic. Additionally, the prevalence of beta coronaviruses circulating in animals and the precedent they have set in jumping into human populations indicates that they pose a continuous threat for future pandemics. Currently, only one therapeutic is approved by the U.S. Food and Drug Administration (FDA) for use in treating COVID-19, remdesivir, although other therapies are authorized for emergency use due to this pandemic being a public health emergency. In this review, twenty-four different treatments are discussed regarding their use against COVID-19 and any potential future coronavirus-associated illnesses. Their traditional use, mechanism of action against COVID-19, and efficacy in clinical trials are assessed. Six treatments evaluated are shown to significantly decrease mortality in clinical trials, and ten treatments have shown some form of clinical efficacy. |
| Databáze: | OpenAIRE |
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