Impact of chronic exposure of rainbow trout, Oncorhynchus mykiss, to low doses of glyphosate or glyphosate-based herbicides

Autor: Jessy Le Du-Carrée, Morgane Danion, Thierry Morin
Přispěvatelé: Laboratoire de Ploufragan-Plouzané-Niort [ANSES], Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Institut Universitaire Européen de la Mer (IUEM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Départment des Côtes d’Armor, Agglomération de Saint Brieuc, Région Bretagne, Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Glyphosate
Health
Toxicology and Mutagenesis
[SDV]Life Sciences [q-bio]
010501 environmental sciences
Hematocrit
MESH: Reproduction
01 natural sciences
MESH: Dose-Response Relationship
Drug
chemistry.chemical_compound
MESH: Animals
MESH: glyphosate [Supplementary Concept]
Mean corpuscular volume
media_common
0303 health sciences
MESH: Oxidative Stress
biology
medicine.diagnostic_test
Reproduction
Glyphosate-based herbicide
Fecundity
MESH: Glycine
Trout
MESH: Water Pollutants
Chemical
MESH: Oncorhynchus mykiss
Oncorhynchus mykiss
[SDV.TOX]Life Sciences [q-bio]/Toxicology
media_common.quotation_subject
Glycine
Aquatic Science
03 medical and health sciences
Animal science
medicine
Animals
14. Life underwater
Ecotoxicity
030304 developmental biology
0105 earth and related environmental sciences
MESH: Herbicides
Dose-Response Relationship
Drug
Herbicides
Pesticide
biology.organism_classification
Oxidative Stress
Immune system
chemistry
13. Climate action
Rainbow trout
Water Pollutants
Chemical
Zdroj: Aquatic Toxicology
Aquatic Toxicology, 2021, 230, pp.105687. ⟨10.1016/j.aquatox.2020.105687⟩
Aquatic Toxicology, Elsevier, 2021, 230, pp.105687-. ⟨10.1016/j.aquatox.2020.105687⟩
Aquatic Toxicology, Elsevier, 2021, 230, pp.105687. ⟨10.1016/j.aquatox.2020.105687⟩
ISSN: 0166-445X
DOI: 10.1016/j.aquatox.2020.105687⟩
Popis: Glyphosate is an herbicidal active substance (AS) entering in the composition of a large diversity of pesticide products (glyphosate-based herbicides; GBH) used in modern intensive agriculture. This compound has a favorable environmental safety profile but was suspected to induce deleterious effects in aquatic organisms, with a potential effect of some associated co-formulants. This study aimed to assess the impact of direct and chronic exposure to glyphosate on the health status of rainbow trout, Oncorhynchus mykiss. A total of 36 genitors were exposed daily for 10 months to a dose of glyphosate representative of environmental concentrations (around 1 μ g L − 1 ) using the AS alone or two GBHs formulations (i.e. Roundup Innovert® and Viaglif Jardin®) and findings were compared to an unexposed control group ( n = 12 ). The effects of chemical exposure on the reproductive capacities, hemato-immunologic functions, energetic metabolism, oxidative stress and specific biomarkers of exposure were analyzed over a period of 4 months covering spawning. A limited mortality between 15% and 30% specific to the spawning occurred under all conditions. No differences were observed in reproduction parameters i.e. mean weights, relative fertility and fecundity. Red blood cell count, hematocrit index, mean corpuscular volume and white blood cell counts were similar for all the sampling dates. Significant changes were observed two months before spawning with a 70% decrease of the proportion of macrophages in trout exposed to Viaglif only and a reduction of 35% of the phagocytic activity in fish exposed to the two GBHs. Trends towards lower levels of expression of tumor necrosis factor- α (between 38% and 66%) were detected one month after the spawning for all contaminated conditions but without being statistically significant. Biomarkers of exposure, i.e. acetylcholine esterase and carbonic anhydrase activities, were not impacted and none of the chemical contaminants disturbed the oxidative stress or metabolism parameters measured. These results suggest that a 10 months exposure of rainbow trout to a concentration of 1 μ g L − 1 of glyphosate administered using the pure active substance or two GBHs did not significantly modify their global health including during the spawning period. The immunological disturbances observed will need to be further explored because they could have a major impact in response to infectious stress.
Databáze: OpenAIRE
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