Determinants and Functional Significance of Renal Parenchymal Volume in Adults
| Autor: | Wassim Khawandi, Andreea Andone, Nana Gletsu-Miller, Samuel Johnson, Rahul Rishi, Deborah A. Baumgarten, Jafar Al-Said, W. Charles O'Neill, Edward Lin |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Epidemiology Body Surface Area Urology Renal function urologic and male genital diseases Critical Care and Intensive Care Medicine Kidney chemistry.chemical_compound Weight loss Internal medicine Medicine Body Size Humans Body surface area Transplantation Creatinine business.industry Organ Size Original Articles Middle Aged medicine.disease Obesity Radiography Endocrinology medicine.anatomical_structure chemistry Nephrology Cohort Female medicine.symptom business Glomerular Filtration Rate |
| Popis: | Summary Background and objectives The significance of renal parenchymal volume and the factors that influence it are poorly understood. Design, setting, participants, & measurements Renal parenchymal volume (RPV) was measured on contrastenhanced CT scans after exclusion of sinus fat and vessels in 224 healthy subjects evaluated as kidney donors and in a separate cohort of 22 severely obese individuals before and after 6 months of weight loss. GFR was measured by iohexol clearance in 76 of the transplant donors. RPV was correlated with age, GFR, and various anthropometric parameters. Results In potential transplant donors, RPV correlated with body surface area (BSA; r 0.68) and was 7% larger in men but did not vary with age or race. Gender and body size were independent determinants of RPV. RPV correlated well with GFR (r 0.62) and accounted for almost all of the variability in a model of GFR that included age, race, gender, and body surface area. GFR correlated more strongly with RPV than with creatinine-based equations. The same relationship between RPV and BSA was observed in obesity, and RPV decreased with weight loss. Conclusions In healthy adults younger than 65 years, renal parenchymal volume is governed by body size and gender but not age or race and is strongly correlated with GFR. This indicates that renal parenchymal volume varies to meet metabolic demand and is closely linked to renal function. Clin J Am Soc Nephrol 6: 70–76, 2011. doi: 10.2215/CJN.00030110 |
| Databáze: | OpenAIRE |
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