A new cognition-enhancing agent, (R)-(-)-1-(benzo[b]thiophen-5-yl)- 2-[2-(N,N-diethylamino)ethoxy]ethanol hydrochloride. Effects on memory impairment in rats generated by cerebral embolization and basal forebrain lesions
| Autor: | Kuniko Mozumi, Hisaaki Chaki, Kazunori Kitamura, Yasushi Nakada, Tetsuo Yamafuji, Tatsuo Kimura, Mutsuko Maekawa, Satoshi Ono, Hirokazu Narita, Yozo Todo |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Diethylamines Pharmaceutical Science Thiophenes Pharmacology Lesion Lethal Dose 50 Mice Prosencephalon medicine Avoidance Learning Idebenone Memory impairment Animals Rats Wistar Hypoxia Nootropic Agents Indeloxazine Basal forebrain Neurotransmitter Agents business.industry Stereoisomerism General Medicine Intracranial Embolism and Thrombosis Rats Monoamine neurotransmitter Anesthesia Tacrine medicine.symptom business Acetylcholine medicine.drug |
| Zdroj: | Biologicalpharmaceutical bulletin. 18(12) |
| ISSN: | 0918-6158 |
| Popis: | The title compound (T-588) has been evaluated for its ameliorating effect on memory impairment generated by cerebral embolization and by a basal forebrain (BF) lesion in male Wistar rats. The memory and learning deficits induced by injection of carbon-microspheres into the internal carotid artery were significantly improved by T-588 at oral dose of 3-10 mg/kg, as determined by an active avoidance response assay, whereas the reference drugs (tacrine, idebenone and indeloxazine) proved almost inactive in the same assay procedure. As far as the embolization was concerned, a significant decrease in cerebral acetylcholine and monoamines was observed. The effect on the memory impairment caused by an electrolytic lesion of the BF was assessed by a passive avoidance task. T-588 exhibited a bell-shaped dose-response curve and was most active at 1 mg/kg (oral dose), while tacrine showed equal activity at 10 mg/kg. |
| Databáze: | OpenAIRE |
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