Involvement of SLC39A6 in gastric adenocarcinoma and correlation of the SLC39A6 polymorphism rs1050631 with clinical outcomes after resection

Autor: Minxian Zhuang, Zaizhong Zhang, Xuehong Fang, Yuan Dang, Pengcheng Weng, Liying Lin, Hui Wang, Lie Wang, Jian Gao, Wenjun Ren, Qiaojia Huang, Chunhong Xiao, Shaoquan Chen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Cancer Research
Cell
Gastroenterology
SLC39A6 rs1050631
0302 clinical medicine
Polymorphism (computer science)
Surgical oncology
Cell Movement
Genotype
Medicine
Cation Transport Proteins
Incidence
Hazard ratio
Middle Aged
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Neoplasm Proteins
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Gene Knockdown Techniques
Adenocarcinoma
Female
Ki67
Research Article
medicine.medical_specialty
China
Prognostic biomarker
High-occurrence area
Transfection
Polymorphism
Single Nucleotide
lcsh:RC254-282
Disease-Free Survival
TOPOII
03 medical and health sciences
Stomach Neoplasms
Internal medicine
Cell Line
Tumor
Genetics
Carcinoma
Humans
Neoplasm Invasiveness
Cell Proliferation
Retrospective Studies
Gastric adenocarcinoma
business.industry
medicine.disease
030104 developmental biology
Cell culture
Neoplasm Recurrence
Local
business
Zdroj: BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)
BMC Cancer
ISSN: 1471-2407
Popis: Background The single-nucleotide polymorphism SLC39A6 rs1050631 is strongly implicated in esophageal squamous cell carcinoma, leading us to question whether it may also play a role in gastric adenocarcima (GA). Methods We genotyped the SLC39A6 rs1050631 in 512 patients who underwent GA resection. All study subjects lived in an area of China with high GA incidence. Genotypes were examined for possible correlation with survival and recurrence. The potential involvement of SLC39A6 in gastric cancer was explored in clinical samples and cell culture studies. Results Multivariable analysis showed that patients with the CT + TT genotype at SLC39A6 rs1050631 were at greater risk of recurrence (hazard ratio, HR 1.387, p = 0.004) and death (HR 1.429, p = 0.002) than patients with CC genotype. Median recurrence-free and overall survival were significantly shorter in patients with the CT + TT genotype (20, 27 months) than in patients with the CC genotype (36, 43 months, p = 0.001, p Conclusion SLC39A6 rs1050631 correlates with post-resection prognosis of GA patients and SLC39A6 may participate in GA onset or progression.
Databáze: OpenAIRE
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