Myeloid Cells Restrict MCMV and Drive Stress- Induced Extramedullary Hematopoiesis through STAT1
| Autor: | Sabine Macho-Maschler, Rita Rom, Mathias Müller, Juliana Kornhoff, Andrea Poelzl, Riem Gawish, Ulrich Kalinke, Luca Ferrarese, Jasmin Svinka, Lena Amenitsch, Natalija Simonović, Zsuzsanna Bago-Horvath, Robert Eferl, Stipan Jonjić, Therese Lederer, Tanja Bulat, Dagmar Stoiber, Mario Biaggio, Michaela Prchal-Murphy, Veronika Sexl, Birgit Strobl, Astrid Krmpotić, Markus Bosmann, Caroline Lassnig |
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| Přispěvatelé: | TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str.7,30625 Hannover, Germany. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Muromegalovirus Myeloid IFN-II receptor Receptor Interferon alpha-beta monocytes signal transducer and activator of transcription Herpesviridae IFN-I receptor IFN-II receptor L-27 receptor TLR9 agonist medicine.disease_cause Virus Replication 0302 clinical medicine TLR9 agonist Myeloid Cells STAT1 Cells Cultured Herpesviridae Receptors Interferon signal transducer and activator of transcription virus diseases IL-27 receptor Herpesviridae Infections Extramedullary hematopoiesis Killer Cells Natural Haematopoiesis medicine.anatomical_structure STAT1 Transcription Factor Bone marrow suppression Hematopoiesis Extramedullary Female monocytes BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti Spleen Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Stress Physiological medicine Animals BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences Receptors Interleukin medicine.disease Mice Inbred C57BL 030104 developmental biology Immunology STAT protein biology.protein 030217 neurology & neurosurgery Gene Deletion IFN-I receptor |
| Zdroj: | Cell Reports Volume 26 Issue 9 Cell reports |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2019.02.017 |
| Popis: | Cytomegalovirus (CMV) has a high prevalence worldwide, is often fatal for immunocompromised patients, and causes bone marrow suppression. Deficiency of signal transducer and activator of transcription 1 (STAT1) results in severely impaired antiviral immunity. We have used cell- type restricted deletion of Stat1 to determine the importance of myeloid cell activity for the defense against murine CMV (MCMV). We show that myeloid STAT1 limits MCMV burden and infection- associated pathology in the spleen but does not affect ultimate clearance of infection. Unexpectedly, we found an essential role of myeloid STAT1 in the induction of extramedullary hematopoiesis (EMH). The EMH- promoting function of STAT1 was not restricted to MCMV infection but was also observed during CpG oligodeoxynucleotide-induced sterile inflammation. Collectively, we provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen. |
| Databáze: | OpenAIRE |
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