| Autor: |
Ming-Lun, Han, Ming-Hsien, Lee, Wei-Jei, Lee, Shu-Chun, Chen, Owaid M, Almalki, Jung-Chien, Chen, Chun-Chi, Wu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Asian Journal of Surgery. 45:2664-2669 |
| ISSN: |
1015-9584 |
| DOI: |
10.1016/j.asjsur.2022.01.120 |
| Popis: |
Gall stone disease was known to increase after bariatric surgery. Ursodeoxycholic acid (UDCA) might reduce the gallstone formation rate after bariatric surgery. However, other option for gallstone prevention was unclear. We reported the result of a randomized trial comparing the gallstone prevention efficacy of probiotics and digestive enzyme versus UDCA.This prospective, randomized trial was held in an institute of Taiwan. Patients were eligible for inclusion if their body-mass index (BMI) was 32.5 kg/m2 or higher with the presence of comorbidity, or 27.5 kg/mw or higher with not-well controlled type 2 diabetes, and were aged 18-65 years. Participant were randomized assigned (1:1:1) to probiotic, digestive enzyme or UDCA. The primary endpoint was assessed in the incidence of gallstone disease at 6 months after surgery. This study is registered with ClinicalTrials.gov. number NCT03247101, and is now completed.From January 2016 to December 2018, of 186 patients screened for eligibility, 152 were randomly assigned to probiotic (52) or digestive enzyme (52) or UDCA (52). In the per-protocol population, mean age was 35.9 years (SD 10.6), mean BMI was 40.3 kg/mProbiotic is not inferior to UDCA regarding gall bladder disease prevention after bariatric surgery at 6 months. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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