In premature luteinization, progesterone induces secretory transformation of the endometrium without impairment of embryo viability
| Autor: | Robert J. Kiltz, Ryszard J. Chetkowski, William R. Salyer |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Biopsy media_common.quotation_subject Uterus Biology Endometrium Andrology Corpus Luteum Pregnancy Internal medicine medicine Humans Embryo Implantation Prospective Studies Ovulation Menstrual Cycle Progesterone Menstrual cycle media_common Oocyte Donation medicine.diagnostic_test Pregnancy Outcome Obstetrics and Gynecology Middle Aged Oocyte medicine.anatomical_structure Endocrinology Reproductive Medicine In utero Female Gonadotropin Endometrial biopsy |
| Zdroj: | Fertility and Sterility. 68:292-297 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(97)81518-x |
| Popis: | Objective: To determine the effect of serum P on endometrial histology in stimulated cycles. Design: Prospective clinical study. Setting: Community hospital-based donor oocyte program. Patient(s): Fertile young oocyte donors and infertile donor oocyte recipients. Intervention(s): Oocyte donors underwent gonadotropin stimulation after midluteal pituitary suppression. Endometrial biopsies were obtained at the time of oocyte retrieval. Main Outcome Measure(s): Endometrial histology and serum P levels in oocyte donors. Pregnancy and implantation rates in oocyte recipients. Result(s): Thirteen biopsy specimens (52.0%) showed in-phase mixed proliferative pattern (days 14 to 15), whereas 12 (48.0%) were secretory (days 16 to 17). On the day of hCG, subjects with secretory endometrium had higher P of 1.7 ng/mL (5.4 nmol/L) than women with the mixed pattern (0.8 ng/mL [2.5 nmol/l]). Progesterone ⩾ 0.9 ng/mL had a 78.6% positive predictive value for secretory transformation. In 75.0% of cycles with secretory endometrium, P was ⩾ 0.9 ng/mL (2.9 nmol/L) as early as 2 days before hCG. Both mixed and secretory patterns were associated with similar clinical pregnancy rates (57.1% and 60.0%, respectively) and delivery rates (38.1% and 50.0%, respectively) in recipients. Conclusion(s): Subtle elevation of P induced secretory endometrial transformation without reduction in embryo viability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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