| Autor: |
Makoto Kuro-o, Ryosuke Ueda, Glicia Maria de Almeida, Kyoji Urayama, Satsuki Endo, Satoshi Kozawa, Shinji Ozaki, Fumihiko Sagawa, Kazuhiro Shiizaki, Yoshinori Yamashita, Hiroshi Kurosu, Sharif Hasan, Thomas N. Sato, Kiyokazu Nakazato |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
iScience, Vol 2, Iss, Pp 238-268 (2018) |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2018.03.014 |
| Popis: |
Summary: Virtually all diseases affect multiple organs. However, our knowledge of the body-wide effects remains limited. Here, we report the body-wide transcriptome landscape across 13–23 organs of mouse models of myocardial infarction, diabetes, kidney diseases, cancer, and pre-mature aging. Using such datasets, we find (1) differential gene expression in diverse organs across all models; (2) skin as a disease-sensor organ represented by disease-specific activities of putative gene-expression network; (3) a bone-skin cross talk mediated by a bone-derived hormone, FGF23, in response to dysregulated phosphate homeostasis, a known risk-factor for kidney diseases; (4) candidates for the signature activities of many more putative inter-organ cross talk for diseases; and (5) a cross-species map illustrating organ-to-organ and model-to-disease relationships between human and mouse. These findings demonstrate the usefulness and the potential of such body-wide datasets encompassing mouse models of diverse disease types as a resource in biological and medical sciences. Furthermore, the findings described herein could be exploited for designing disease diagnosis and treatment. : Gene Network; Experimental Models in Systems Biology; Transcriptomics Subject Areas: Gene Network, Experimental Models in Systems Biology, Transcriptomics |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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