Beyond the AMPA receptor: Diverse roles of SynDIG/PRRT brain-specific transmembrane proteins at excitatory synapses

Autor: Elva Dίaz
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
1.1 Normal biological development and functioning
Paroxysmal
AMPA receptor
Neurotransmission
Biology
030226 pharmacology & pharmacy
Synaptic vesicle
Synaptic Transmission
Article
SynDIG4
Synaptic plasticity
03 medical and health sciences
SynDIG1
0302 clinical medicine
Excitatory synapse
Underpinning research
Receptors
AMPA
Drug Discovery
Paroxysmal kinesigenic dyskinesia
Humans
kinesigenic dyskinesia
Pharmacology & Pharmacy
Receptors
AMPA
AMPA receptor auxiliary factor
Pharmacology
musculoskeletal
neural
and ocular physiology
Neurosciences
Glutamate receptor
Brain
Membrane Proteins
Pharmacology and Pharmaceutical Sciences
Transmembrane protein
Brain Disorders
030104 developmental biology
nervous system
CP-AMPARs
Neurological
Synapses
Excitatory postsynaptic potential
PRRT1
PRRT2
Neuroscience
Palmitoylation
Biotechnology
Zdroj: Current opinion in pharmacology
ISSN: 1471-4973
1471-4892
Popis: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) are responsible for fast excitatory transmission in the brain. Deficits in synaptic transmission underlie a variety of neurological and psychiatric disorders. However, drugs that target AMPARs are challenging to develop, given the central role played in neurotransmission. Targeting AMPAR auxiliary factors offers an innovative approach for achieving specificity without altering baseline synaptic transmission. This review focuses on the SynDIG/proline-rich transmembrane protein (PRRT) family of AMPAR-associated transmembrane proteins. Although these factors are related based on sequence similarity, the proteins have evolved diverse actions at excitatory synapses that are not limited to the traditional role ascribed to an AMPAR auxiliary factor. SynDIG4/PRRT1 acts as a typical AMPAR auxiliary protein, while PRRT2 functions at presynaptic sites to regulate synaptic vesicle dynamicsand is the causative gene for neurological paroxysmal disorders in humans. SynDIG/PRRT proteins are members of a larger superfamily that also include antiviral proteins known to restrict fusion between host and viral membranesand share some interesting characteristics.
Databáze: OpenAIRE
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