Significance of Serum Bile Acids in Small Bowel Allograft Rejection in Pigs
| Autor: | Thierry Yandza, Jean Gugenheim, Marie-Christine Saint-Paul, Xavier Hébuterne, Veronique M. Braud, Marie F Gerhardt |
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| Přispěvatelé: | Service de Chirurgie Digestive et Transplantation Hépatique, Hôpital Archet II, Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie, Groupe Hospitalier Paris Saint-Joseph, Service d'Anatomo-Pathologie, Centre Hospitalier Universitaire de Nice (CHU Nice), Service de Gastroentérologie (Pôle Digestif) |
| Rok vydání: | 2009 |
| Předmět: |
Graft Rejection
medicine.medical_specialty MESH: Intestine Small Swine medicine.drug_class medicine.medical_treatment MESH: Graft Rejection MESH: Bile Acids and Salts Biology Rejection Gastroenterology Bile Acids and Salts 03 medical and health sciences 0302 clinical medicine Internal medicine Intestine Small MESH: Transplantation Homologous medicine Animals Transplantation Homologous MESH: Animals MESH: Swine Pig Transplantation Bile acid Pig model Histology Serum samples Bile acids Intestine 3. Good health Intestinal histology Allograft rejection 030220 oncology & carcinogenesis [SDV.IMM]Life Sciences [q-bio]/Immunology Female 030211 gastroenterology & hepatology MESH: Female Allotransplantation |
| Zdroj: | Transplantation Transplantation, Lippincott, Williams & Wilkins, 2009, 87 (1), pp.24-8. ⟨10.1097/TP.0b013e3181902b35⟩ |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/tp.0b013e3181902b35 |
| Popis: | International audience; OBJECTIVES: To examine changes in individual bile acids in serum in a pig model of allogenic small bowel transplantation. METHODS: Seventeen pigs were divided into two groups: group 1 (n=10), controls; group 2 (n=7), allotransplantation, nonimmunosuppressed recipients. Both groups received a segmental intestine. Intestinal specimens for histologic studies were obtained at the end of cold flushing (T0) and on postoperative day 8 (T1). Total and individual bile acid concentrations were measured in serum samples taken at T0 and T1. RESULTS: All animals survived until the end of the study. In group 1, intestinal histology revealed no significant changes between T0 and T1 specimens. In contrast, in group 2, graft histology revealed moderate to severe rejection at T1 in all specimens. In contrast to group 1, serum levels of total bile acids increased significantly in group 2 at T1 compared with baseline (P=0.001). The increase was due to secondary bile acids which were significantly higher at T1 compared with baseline (P=0.0003). In contrast, secondary bile acids increased but not significantly at T1 in group 1 compared with baseline (P=0.056). CONCLUSION: Our study suggests that total and secondary serum bile acids may be a useful diagnostic tool for the diagnosis of acute intestinal rejection. |
| Databáze: | OpenAIRE |
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