Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses
| Autor: | Florian Kreppel, Franziska Schandock, Janis A. Müller, Paulina Gajda, Kaja Zuwala, Jan Münch, Kaja Borup Løvschall, Anna H. F. Andersen, Mirja Harms, Martin Tolstrup, Camilla Frich Riber, Annika Röcker, Alexander N. Zelikin |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Polymers viruses Biomedical Engineering Human immunodeficiency virus (HIV) Pharmaceutical Science broad spectrum antivirals Biology medicine.disease_cause Antiviral Agents Immunodeficiency virus Zika virus Biomaterials 03 medical and health sciences Hcv genotype 1 Chlorocebus aethiops medicine Journal Article Animals Humans Vero Cells Full Paper Polymethacrylic Acids Zika Virus Full Papers Ebolavirus medicine.disease biology.organism_classification Virology Microbicides for sexually transmitted diseases HEK293 Cells polyanions 030104 developmental biology Severe acute respiratory syndrome-related coronavirus microbicides Virus Diseases Immunology Rabies |
| Zdroj: | Schandock, F, Riber, C F, Röcker, A, Müller, J A, Harms, M, Gajda, P, Zuwala, K, Andersen, A H F, Løvschall, K B, Tolstrup, M, Kreppel, F, Münch, J & Zelikin, A N 2017, ' Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses ', Advanced Healthcare Materials . https://doi.org/10.1002/adhm.201700748 Advanced Healthcare Materials |
| Popis: | Viral pathogens continue to constitute a heavy burden on healthcare and socioeconomic systems. Efforts to create antiviral drugs repeatedly lag behind the advent of pathogens and growing understanding is that broad‐spectrum antiviral agents will make strongest impact in future antiviral efforts. This work performs selection of synthetic polymers as novel broadly active agents and demonstrates activity of these polymers against Zika, Ebola, Lassa, Lyssa, Rabies, Marburg, Ebola, influenza, herpes simplex, and human immunodeficiency viruses. Results presented herein offer structure–activity relationships for these pathogens in terms of their susceptibility to inhibition by polymers, and for polymers in terms of their anionic charge and hydrophobicity that make up broad‐spectrum antiviral agents. The identified leads cannot be predicted based on prior data on polymer‐based antivirals and represent promising candidates for further development as preventive microbicides. Broad spectrum antiviral agents are designed through systematic variation of the polymer composition, specifically the nature of the anionic charge of the polymer and hydrophobicity of the backbone. Structure–function relationship reveals unexpected lead candidates with inhibitory antiviral activity against all tested enveloped viruses. |
| Databáze: | OpenAIRE |
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