The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2
| Autor: | Enrique Roche, Hugo J. Bello, David C. Noriega, Alfredo Córdova-Martínez, Alberto Caballero-García |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
2420 Virología
Medicine (General) COVID-19 Vaccines 2412 Inmunología medicine.medical_treatment Context (language use) vitamin D Review immunomodulation Virus Dengue fever COVID-19 (Disease) R5-920 Vitamin D and neurology Humans Medicine SARS-CoV-2 business.industry COVID-19 Common cold Vitamins General Medicine Vacunación medicine.disease Micronutrient vaccination Vaccination Immunology business Adjuvant |
| Zdroj: | Medicina, Vol 57, Iss 1321, p 1321 (2021) Medicina |
| ISSN: | 1648-9144 |
| Popis: | Producción Científica Vaccines are the only way to reduce the morbidity associated to SARS-CoV-2 infection. The appearance of new mutations urges us to increase the effectiveness of vaccines as a complementary alternative. In this context, the use of adjuvant strategies has improved the effectiveness of different vaccines against virus infections such as dengue, influenza, and common cold. Recent reports on patients infected by COVID-19 reveal that low levels of circulating vitamin D correlate with a severe respiratory insufficiency. The immunomodulatory activity of this micronutrient attenuates the synthesis of pro-inflammatory cytokines and at the same time, increases antibody production. Therefore, the present review proposes the use of vitamin D as adjuvant micronutrient to increase the efficacy of vaccines against SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
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