Reduction of hypoxic pulmonary vasoconstriction by diethyl ether in the isolated perfused cat lung: the effect of acidosis and alkalosis
| Autor: | A. R. Tait, M. K. Sykes, J. B. Hurtig |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Pulmonary Circulation
Alkalosis Time Factors Blood Pressure Pulmonary Artery Ether chemistry.chemical_compound Left atrial Hypoxic pulmonary vasoconstriction Medicine Pulmonary blood flow Animals Hypoxia Lung Acidosis business.industry General Medicine Oxygenation medicine.disease Perfusion Ethyl Ethers Anesthesiology and Pain Medicine medicine.anatomical_structure chemistry Anesthesia Cats Vascular Resistance Diethyl ether medicine.symptom business |
| Zdroj: | Canadian Anaesthetists' Society journal. 24(4) |
| ISSN: | 0008-2856 |
| Popis: | Hypoxic pulmonary vasoconstriction is a protective mechanism diverting pulmonary blood flow away from hypoxic areas toward more optimally oxygenated lung units. Venous admixture is reduced and arterial oxygenation improved. Hypoxic pulmonary vasoconstriction was demonstrated during acidosis, alkalosis and normal pH in the isolated perfused cat lung under conditions of constant flow and constant left atrial and airway pressures. Two per cent diethyl ether markedly reduced hypoxic vasoconstriction under all acid-base conditions, the hypoxic pressor response returning after wash-out of diethyl ether. Modification of hypoxic pulmonary vasoconstriction during acid-base disturbances and possible implications of concurrent anaesthetic administration are discussed. |
| Databáze: | OpenAIRE |
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