Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection
| Autor: | Roberta Aparecida Duarte, L.P.C. Faggioni, Celso T. Mendes-Junior, Eduardo Antônio Donadi, Christiane Pienna Soares, Isabela Jubé Wastowski, Janaina Cristiana de Oliveira Crispim, L. T. Saber, João Santana da Silva, Roberto Silva Costa |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Pathology Adolescent medicine.medical_treatment Immunology Human leukocyte antigen Gastroenterology Chronic allograft nephropathy HLA Antigens Internal medicine HLA-G medicine Immunology and Allergy Humans Prospective Studies Kidney transplantation Aged Heart transplantation HLA-G Antigens Transplantation Kidney business.industry Incidence Histocompatibility Antigens Class I Middle Aged medicine.disease Kidney Transplantation Tacrolimus surgical procedures operative medicine.anatomical_structure Cross-Sectional Studies Female business |
| Zdroj: | Transplant immunology. 18(4) |
| ISSN: | 0966-3274 |
| Popis: | HLA-G is a non-classic Human Leukocyte Antigen (HLA-G) Class I of low polymorphism and restricted tissue distribution that displays tolerogenic functions. In heart transplantation and in combined liver/renal allograft transplantation, the expression of HLA-G has been associated with a lower incidence of acute graft rejection episodes and absence of chronic dysfunction. Since the expression of HLA-G in renal biopsies has been investigated only in few patients who received a combined kidney and liver transplant, in this study we performed a cross-sectional study, systematically comparing the expression of HLA-G in post-transplanted renal grafts, stratifying patients according to the presence or absence of rejection.Seventy-three renal specimens (10 with acute rejection and 13 with chronic allograft nephropathy, and 50 with no signs of rejection) were immunohistochemically evaluated for HLA-G expression.In the group as a whole, HLA-G molecules were detected in 40 cases (54.8%). Among specimens that presented HLA-G expression, 2 out of 40 (5%) exhibited acute rejection, 2 (5%) exhibited chronic allograft nephropathy, and the remaining 36 (90%) exhibited no signs of rejection. The comparison between patients with rejection and those without rejection showed that the expression of HLA-G was significantly increased in specimens exhibiting no signs of rejection (p0.0001). Considering only patients with acute rejection, 8 out of 10 patients showed no HLA-G expression in their kidney biopsies when compared to patients exhibiting no signs of rejection and absence of HLA-G was observed in 14 out of 50 (p=0.0032). Similarly, considering only patients with chronic allograft nephropathy, absence of HLA-G expression was observed in 11 out of 13 specimens, whereas in patients without rejection absence of HLA-G was observed in 14 out of 50 (p=0.003). Therapy with tacrolimus was significantly associated with the expression of HLA-G and a better graft prognosis.Our results suggest that HLA-G expression in the kidney allograft and the use of tacrolimus are associated with a lower frequency of acute renal rejection and chronic allograft nephropathy. |
| Databáze: | OpenAIRE |
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