Clinical characteristics and outcomes of community and hospital-acquired Acinetobacter baumannii bacteremia
| Autor: | Yohei Doi, Sarunyou Chusri, Boonsri Charernmak, Kamonnut Singkhamanan, Kachornsakdi Silpapojakul, Virasakdi Chongsuvivatwong, Thanaporn Hortiwakul |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Acinetobacter baumannii Male lcsh:QR1-502 Bacteremia Kaplan-Meier Estimate lcsh:Microbiology 0302 clinical medicine Risk Factors polycyclic compounds Immunology and Allergy 030212 general & internal medicine biology Virulence Mortality rate General Medicine Middle Aged Antimicrobial Hospitals Anti-Bacterial Agents Community-Acquired Infections Infectious Diseases Health evaluation Larva Female Acinetobacter Infections Microbiology (medical) Adult medicine.medical_specialty animal structures 030106 microbiology Microbial Sensitivity Tests 03 medical and health sciences Internal medicine medicine Animals Humans Mortality Survival analysis Aged Retrospective Studies General Immunology and Microbiology Adult patients business.industry Retrospective cohort study biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease bacterial infections and mycoses Disease Models Animal Carbapenems bacteria business |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 52, Iss 5, Pp 796-806 (2019) |
| ISSN: | 1684-1182 |
| Popis: | Purpose: We aimed to characterize clinical manifestations of the patients with bacteremia due to community-acquired Acinetobacter baumannii and evaluate the outcomes of these patients. Methods: We conducted a retrospective study to include adult patients with A. baumannii bacteremia and then classified them into two groups: community-acquired A. baumannii bacteremia and hospital-acquired A. baumannii bacteremia. Characteristics and outcomes between 2 groups were compared. The Galleria mellonella infection survival model was used to determine the virulence of A. baumannii in these 2 groups. Results: There were 63 patients with A. baumannii bacteremia: 21 patients with community-acquired (CA) bacteremia and 42 patients with hospital-acquired (HA) bacteremia. Three patients with CA bacteremia were excluded due to healthcare-associated risks of infection. The remaining 18 patients with CA bacteremia had carbapenem-susceptible A. baumannii (CA-CSAB). Among the 42 patients with HA bacteremia, 11 patients had carbapenem-susceptible A. baumannii (HA-CSAB) and 31 patients had carbapenem-resistant A. baumannii (HA-CRAB). The 30-day mortality rates of those with CA-CSAB did not differ from those with HA-CSAB bacteremia but were significantly lower than those with HA-CRAB (p = 0.003). The factors influencing 30-day mortality were infection with CRAB (p = 0.004), appropriate empirical antimicrobial therapy (p = 0.002), and higher Acute Physiology and Chronic Health Evaluation II score (p |
| Databáze: | OpenAIRE |
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