Antidiabetic Effects of Yam (Dioscorea batatas) and Its Active Constituent, Allantoin, in a Rat Model of Streptozotocin-Induced Diabetes

Autor: Mahbubur Rahman, Chong Sam Na, Gi Beum Kim, Jin Shang Kim, Choon Ho Song, Hyung Sub Kang, Shang Jin Kim, Hyeon Kyu Go
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Blood Glucose
Male
Antioxidant
antioxidant
endocrine system diseases
medicine.medical_treatment
Antioxidants
Rats
Sprague-Dawley
chemistry.chemical_compound
Glucagon-Like Peptide 1
diabetic
rat
Allantoin
Nutrition and Dietetics
C-Peptide
Dioscorea
Malondialdehyde
Glucagon-like peptide-1
Lipoproteins
LDL
Dioscorea batatas
lcsh:Nutrition. Foods and food supply
insulin
hyperglycemia
glucagon-like peptide-1
medicine.drug
medicine.medical_specialty
lcsh:TX341-641
Article
Diabetes Mellitus
Experimental
Internal medicine
Diabetes mellitus
medicine
Animals
Hypoglycemic Agents
Glycated Hemoglobin
glucagon-likepeptide-1
Plant Extracts
Superoxide Dismutase
Insulin
nutritional and metabolic diseases
medicine.disease
Streptozotocin
Oxidative Stress
Endocrinology
chemistry
Glycated hemoglobin
Food Science
Phytotherapy
Zdroj: Nutrients
Nutrients, Vol 7, Iss 10, Pp 8532-8544 (2015)
Nutrients(7): 10
Nutrients; Volume 7; Issue 10; Pages: 8532-8544
Volume 7
Issue 10
Pages 8532-8544
ISSN: 2072-6643
Popis: The objective of this study was to investigate the therapeutic efficacies of crude yam (Dioscorea batatas) powder (PY), water extract of yam (EY), and allantoin (the active constituent of yam) in streptozotocin (STZ)-induced diabetic rats with respect to glucose, insulin, glucagon-like peptide-1 (GLP-1), C-peptide, glycated hemoglobin (HbAlc), lipid metabolism, and oxidative stress. For this purpose, 50 rats were divided into five groups: normal control (NC), diabetic control (STZ), and STZ plus treatment groups (STZ + PY, STZ + EY, and STZ + allantoin). After treatment for one-month, there was a decrease in blood glucose: 385 ± 7 in STZ, 231 ± 3 in STZ + PY, 214 ± 11 in STZ + EY, and 243 ± 6 mg/dL in STZ + allantoin, respectively. There were significant statistical differences (p <
0.001) compared to STZ (100%): 60% in STZ + PY, 55% in STZ + EY, and 63% in STZ + allantoin. With groups in the same order, there were significant decreases (p <
0.001) in HbAlc (100% as 24.4 ± 0.6 ng/mL, 78%, 75%, and 77%), total cholesterol (100% as 122 ± 3 mg/dL, 70%, 67%, and 69%), and low-density lipoprotein (100% as 29 ± 1 mg/dL, 45%, 48%, and 38%). There were also significant increases (p <
0.001) in insulin (100% as 0.22 ± 0.00 ng/mL, 173%, 209%, and 177%), GLP-1 (100% as 18.4 ± 0.7 pmol/mL, 160%, 166%, and 162%), and C-peptide (100% as 2.56 ± 0.10 ng/mL, 129%, 132%, and 130%). The treatment effectively ameliorated antioxidant stress as shown by a significant decrease (p <
0.001) in malondialdehyde (100% as 7.25 ± 0.11 nmol/mL, 87%, 86%, and 85%) together with increases (p <
0.01) in superoxide dismutase (100% as 167 ± 6 IU/mL, 147%, 159%, and 145%) and reduced glutathione (100% as 167 ± 6 nmol/mL, 123%, 141%, and 140%). The results indicate that yam and allantoin have antidiabetic effects by modulating antioxidant activities, lipid profiles and by promoting the release of GLP-1, thereby improving the function of β-cells maintaining normal insulin and glucose levels.
Databáze: OpenAIRE
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