Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype
| Autor: | Fontanini, Gabriella, Vignati, S, Bigini, D, Mussi, Alfredo, Lucchi, H, Angeletti, Ca, Pingitore, Raffaele, Pepe, S, Basolo, Fulvio, 1995, Bevilacqua G. Eur J. C. a. n. c. e. r., 31a:178, 83 |
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| Přispěvatelé: | G., Fontanini, S., Vignati, D., Bigini, A., Mussi, H., Lucchi, C. A., Angeletti, R., Pingitore, Pepe, Stefano, F., Basolo, G. B. e. v. i. l. a. c. q. u., A. |
| Rok vydání: | 1995 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Lung Neoplasms EGFR Cell Adenocarcinoma NSCLC Carcinoma Non-Small-Cell Lung Proliferating Cell Nuclear Antigen medicine Humans Epidermal growth factor receptor Receptor Grading (tumors) Lung biology business.industry Prognosis medicine.disease Immunohistochemistry nodal metastasis Proliferating cell nuclear antigen ErbB Receptors medicine.anatomical_structure Oncology Lymphatic Metastasis Carcinoma Squamous Cell biology.protein Carcinoma Large Cell Female business |
| Zdroj: | European Journal of Cancer. 31:178-183 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/0959-8049(93)00421-m |
| Popis: | Epidermal growth factor receptor (EGFr) levels were evaluated in paraffin-embedded tumour specimens of non-small cell lung cancer (NSCLC) from 176 patients who underwent surgical resection. The EGFr expression was evaluated by immunocytochemical assay using a monoclonal antibody which recognises the external domain of the receptor. EGFr immunoreactivity was significantly higher in squamous than in non-squamous cell carcinomas (P = 0.0009). Hilar and/or mediastinal nodal involvement was found in 29 of 105 (27.4%) squamous cancers, and in this group of patients, the mean of EGFr positive cells was significantly higher than that of patients without nodal involvement (P = 0.01). No significant correlations were found between the expression of EGFr and other clinicopathological or biological parameters such as T-status, grading, proliferative activity. EGFR is suggested to represent a useful indicator of nodal metastasis in NSCLC. |
| Databáze: | OpenAIRE |
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