Parallel pathways for sound processing and functional connectivity among layer 5 and 6 auditory corticofugal neurons
| Autor: | Daniel B. Polley, Ross S. Williamson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
corticothalamic Auditory Pathways Mouse QH301-705.5 Efferent Science Sensory system Biology Stimulus (physiology) computer.software_genre Auditory cortex Ntsr1 General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine Thalamus Interneurons Neural Pathways Animals Biology (General) Audio signal processing Auditory Cortex Neurons General Immunology and Microbiology General Neuroscience Functional connectivity General Medicine corticofugal Sound 030104 developmental biology descending efferent Medicine computer Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | eLife, Vol 8 (2019) eLife |
| Popis: | Cortical layers (L) 5 and 6 are populated by intermingled cell-types with distinct inputs and downstream targets. Here, we made optogenetically guided recordings from L5 corticofugal (CF) and L6 corticothalamic (CT) neurons in the auditory cortex of awake mice to discern differences in sensory processing and underlying patterns of functional connectivity. Whereas L5 CF neurons showed broad stimulus selectivity with sluggish response latencies and extended temporal non-linearities, L6 CTs exhibited sparse selectivity and rapid temporal processing. L5 CF spikes lagged behind neighboring units and imposed weak feedforward excitation within the local column. By contrast, L6 CT spikes drove robust and sustained activity, particularly in local fast-spiking interneurons. Our findings underscore a duality among sub-cortical projection neurons, where L5 CF units are canonical broadcast neurons that integrate sensory inputs for transmission to distributed downstream targets, while L6 CT neurons are positioned to regulate thalamocortical response gain and selectivity. |
| Databáze: | OpenAIRE |
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