Pathogenesis of psoriasis in the 'omic' era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis in psoriasis
| Autor: | Adrianna Radulska, Bogusław Nedoszytko, Rafał Czajkowski, Aleksandra Batycka-Baran, Andrzej Slominski, Radomir M. Slominski, Marta Sobalska-Kwapis, Iwona T. Dobrucki, Lawrence W. Dobrucki, Dominik Samotij, Dorota Krasowska, Roman Nowicki, Aneta Szczerkowska-Dobosz, Marta Stawczyk-Macieja, Leszek Kalinowski, Anna Janaszak-Jasiecka, Justyna Szczęch, Dorota Purzycka-Bohdan, Edyta Reszka, Michał A. Żmijewski, Dominik Strapagiel, Agnieszka Owczarczyk-Saczonek, Magdalena Górecka-Sokołowska, Adam Reich, Joanna Bartosińska |
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| Rok vydání: | 2020 |
| Předmět: |
Systemic disease
Dermatology Disease Bioinformatics metabolic syndrome 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Insulin resistance Psoriasis medicine Immunology and Allergy Risk factor Internal medicine proteomic nutrigenomics business.industry psoriasis medicine.disease metabolomics RC31-1245 Obesity Nutrigenomics inflammation RL1-803 Metabolic syndrome business |
| Zdroj: | Advances in Dermatology and Allergology, Vol 37, Iss 4, Pp 452-467 (2020) |
| ISSN: | 1642-395X |
| DOI: | 10.5114/ada.2020.98284 |
| Popis: | Psoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and the production of inflammatory mediators involved in the development of both psoriasis and metabolic disorders. However, in psoriasis the activation of the Th17/IL-17 and the abnormalities in the Th17/Treg balance axis are observed, but this pathomechanism does not fully explain the frequent occurrence of metabolic disorders. Therefore, there is a need to look for better biomarkers in the diagnosis, prognosis and monitoring of concomitant disorders and therapeutic effects in psoriasis. In addition, the education on the use of a proper diet as a prophylaxis for the development of the above disorders is an important element of holistic care for a patient with psoriasis. Diet may affect gene expression due to epigenetic modification which encompasses interactions of environment, nutrition and diseases. Patients with psoriasis should be advised to adopt proper diet and dietician support. |
| Databáze: | OpenAIRE |
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