Ornamental morphology of ionic liquid functionalized ternary doped N, P, F and N, B, F-reduced graphene oxide and their prevention activities of bacterial biofilm-associated with orthopedic implantation
Autor: | Balaji Murugesan, Nithya Pandiyan, Selvam Samayanan, Jegatheeswaran Sonamuthu, Sundrarajan Mahalingam, Mayakrishnan Arumugam, Muthulakshmi Veerasingam |
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Rok vydání: | 2019 |
Předmět: |
Materials science
Biocompatibility Oxide Ionic Liquids Biocompatible Materials Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention Biomaterials chemistry.chemical_compound law Escherichia coli medicine Ions Osteoblasts Tissue Engineering Orthopedic Equipment Graphene Biofilm Oxides Osteoblast Bacterial Infections 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure Chemical engineering chemistry Mechanics of Materials Biofilms Pseudomonas aeruginosa Ionic liquid Surface modification Graphite 0210 nano-technology Hybrid material |
Zdroj: | Materials Science and Engineering: C. 98:1122-1132 |
ISSN: | 0928-4931 |
Popis: | The multifunctional biological active material design for bone tissue engineering is essential to induce osteoblast cell proliferation and attachment. Adhesion of bacteria on biomaterials to produce biofilms can be major contributors to the pathogenesis of implant material associated infections. This research work focuses on NPF& NBF elemental doping and functionalization of reduced graphene oxide using an imidazolium-based ionic liquid such as BMIM PF6 and BMIM BF4 by hydrothermal method. The resulting tri doped reduced graphene oxide (NPF-rGO and NBF-rGO) composite was further used as a scaffold for bone tissue engineering and anti-biofilm activities. The observation of the effect of NPF-rGO and NBF-rGO on the morphology, adhesion and cell proliferation of HOS cell was investigated. Moreover, the tri doped composite tested its antibiofilm properties against B. subtilis, E. coli, K. pneumoniae, and P. aeruginosa pathogenic bacteria. In-vitro studies clearly show the effectiveness of N, P, B, and F doping promoting the rGO mineralization, biocompatibility, and destruction of bacterial biofilm formation. The result of this study suggests that NPF-rGO and NBF-rGO hybrid material will be a promising scaffold for bone reaeration and implantation with a minimal bacterial infection. |
Databáze: | OpenAIRE |
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